Introduction To assess the within-class variation in kidney outcomes following initiation of sulfonylurea therapy. Research design and methods We used claims data of enrollees in commercial, Medicare Advantage, and traditional Medicare health plans between 2014 and 2021 to emulate a target trial including adults ≥21 years with type 2 diabetes at moderate cardiovascular risk to […]
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Cooperative Action of Cathepsin K Inhibitor and hUMSC-EVs in Attenuating Ferroptosis Sensitivity for Superior Diabetic Wound Healing
Refractory chronic diabetic wounds severely threaten patient survival; however, current treatments do not adequately promote healing. Cathepsin K (CTSK), a collagen-degrading protease upregulated in early diabetic wounds, presents a potential therapeutic target, and human umbilical cord mesenchymal stem cell–derived extracellular vesicles (hUMSC-EVs) show promise in regeneration but are associated with challenges related to production yield […]
Read MoreDiabetes Spotlight: Jonathan Campbell, PhD—Understanding Incretins Through α-Cell–to–β-Cell Communication and Receptor Signaling Pathways
“It was always sports,” Jonathan Campbell says, describing his childhood. He grew up in Toronto, where his father worked as a hydrogeologist and his mother as a grade school teacher. His initial interest was soccer, but by high school his focus had shifted entirely to basketball. “I spent a lot of time on a basketball […]
Read MoreBeyond Blood Sugar: Exploring the Contribution of Metabolic Syndrome to Peripheral Neuropathy
American Neuromuscular Foundation10.13039/100025799Mid-career Research Grant Source link
Read MoreHippo–YAP Signaling Drives Epigenetic Vulnerability in the Diabetic Heart via the miR-22-3p–SIRT1 Axis: Linking Metabolic Stress to Chromatin Control
National Institute of Diabetes and Digestive and Kidney Diseases10.13039/100000062R01-DK123259 Source link
Read MoreIssues and Events
Issues and Events Source link
Read MoreCD8 + Memory T Cells Encode Obesogenic Memory in White Adipose Tissue
Obesity is associated with systemic energy imbalance and leads to a wide range of metabolic complications, including type 2 diabetes, fatty liver disease, and cardiovascular disorders. Therapeutic strategies for obesity, including lifestyle interventions such as exercise and dietary modification, bariatric surgery, and glucagon-like peptide 1 receptor agonists, have been widely implemented (1). However, rapid weight […]
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GLP-1 Drugs Like Ozempic, Mounjaro Can Quiet ‘Food Noise’
Share on PinterestGLP-1 drugs may help reduce food cravings, leading to healthier eating habits that contribute to weight loss. Image Credit: Juan Moyano/Stocksy A recent study found that using GLP-1 drugs, such as Ozempic and Mounjaro, can help reduce food cravings. The researchers found that GLP-1 medications can reduce “food noise” better than behavioral therapy […]
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Wegovy Helps Reduce Migraine Severity, Especially in Women
Share on PinterestA new study found that women using semaglutide had a reduction in their use of triptans, a drug commonly prescribed for migraine. Victor Bordera/Stocksy A study has found that treatment with semaglutide led to reduced triptan usage in women. However, no significant effect was observed in men with overweight or obesity. Experts say […]
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Special Edition: What's Next—Cortisol, Metabolism & Future Innovation, Part 4
Is hypercortisolism the hidden culprit in a significant proportion of both difficult-to-treat diabetes and resistant hypertension? In part 4 of our special series, Dr. Neil Skolnik speaks with John Buse, MD to explore the effects of hypercortisolism, until just recently considered a vanishingly rare condition. This special episode is sponsored with support from Corcept. Please […]
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