“It was always sports,” Jonathan Campbell says, describing his childhood. He grew up in Toronto, where his father worked as a hydrogeologist and his mother as a grade school teacher. His initial interest was soccer, but by high school his focus had shifted entirely to basketball. “I spent a lot of time on a basketball […]
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Beyond Blood Sugar: Exploring the Contribution of Metabolic Syndrome to Peripheral Neuropathy
American Neuromuscular Foundation10.13039/100025799Mid-career Research Grant Source link
Read MoreHippo–YAP Signaling Drives Epigenetic Vulnerability in the Diabetic Heart via the miR-22-3p–SIRT1 Axis: Linking Metabolic Stress to Chromatin Control
National Institute of Diabetes and Digestive and Kidney Diseases10.13039/100000062R01-DK123259 Source link
Read MoreComment on Shah and Ayala. Interpreting Stage-Dependent Changes in Semaglutide Response: From Patterns to Mechanisms
The study by Shah and Ayala (1) offers a valuable temporal dissection of semaglutide’s effects on feeding behavior, energy expenditure (EE), and substrate oxidation in obese mice. By distinguishing rapid, gradual, and maintenance phases of weight loss and extending observations into the posttreatment period, the authors provide a timely framework for understanding the evolving physiology […]
Read MoreComment on Uddin et al. Interpreting Retinal Hypoxia in Early Diabetes
We read with interest the article by Uddin et al. (1) that was recently published in Diabetes. The authors present an in vivo imaging methodology using HYPOX-4 to visualize retinal hypoxia in early diabetes. This approach may help advance our understanding of diabetic retinopathy (DR) pathophysiology and aid in identifying preclinical biomarkers. Source link
Read MoreIssues and Events
Issues and Events Source link
Read MoreComment on Lin et al. Reconsidering Adipose Tissue Lipolysis Dysfunction: Evidence for a Distal Machinery Defect Beyond Insulin Resistance
In their recent article in Diabetes, Lin et al. (1) report an exceptionally strong correlation (r = −0.93) between insulin- and niacin-mediated suppression of FFA-palmitate Ra. Because these agents act through distinct proximal signaling pathways, this correlation, not only notable, is mechanistically constraining and directly informs the interpretation of adipose tissue (AT) dysfunction in obesity and […]
Read MoreCD8 + Memory T Cells Encode Obesogenic Memory in White Adipose Tissue
Obesity is associated with systemic energy imbalance and leads to a wide range of metabolic complications, including type 2 diabetes, fatty liver disease, and cardiovascular disorders. Therapeutic strategies for obesity, including lifestyle interventions such as exercise and dietary modification, bariatric surgery, and glucagon-like peptide 1 receptor agonists, have been widely implemented (1). However, rapid weight […]
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GLP-1 Drugs Like Ozempic, Mounjaro Can Quiet ‘Food Noise’
Share on PinterestGLP-1 drugs may help reduce food cravings, leading to healthier eating habits that contribute to weight loss. Image Credit: Juan Moyano/Stocksy A recent study found that using GLP-1 drugs, such as Ozempic and Mounjaro, can help reduce food cravings. The researchers found that GLP-1 medications can reduce “food noise” better than behavioral therapy […]
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Wegovy Helps Reduce Migraine Severity, Especially in Women
Share on PinterestA new study found that women using semaglutide had a reduction in their use of triptans, a drug commonly prescribed for migraine. Victor Bordera/Stocksy A study has found that treatment with semaglutide led to reduced triptan usage in women. However, no significant effect was observed in men with overweight or obesity. Experts say […]
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