The study by Shah and Ayala (1) offers a valuable temporal dissection of semaglutide’s effects on feeding behavior, energy expenditure (EE), and substrate oxidation in obese mice. By distinguishing rapid, gradual, and maintenance phases of weight loss and extending observations into the posttreatment period, the authors provide a timely framework for understanding the evolving physiology of glucagon-like peptide 1 (GLP-1) receptor agonist therapy—particularly relevant given the growing recognition of heterogeneous and dynamic clinical responses.
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