Author: sugaradmin

Introduction and Objective: Aging is the strongest risk factor for T2D, yet how age-dependent changes in energy-regulating tissues drive metabolic decline remains unclear. Brown adipose tissue (BAT) plays a role in adaptive thermogenesis and glucose metabolism, but whether aging alters BAT remodeling in a stage-dependent manner is unknown.Methods: We performed integrated metabolic phenotyping and single-cell […]

Introduction and Objective: The type 2 diabetes susceptibility gene GPSM1 is linked to impaired muscle function in patients, though its molecular mechanisms remain unknown. This study explores how GPSM1 regulates skeletal muscle metabolism and motor performance.Methods: Skeletal muscle-specific GPSM1 knockout (GPSM1MKO) mice were generated and maintained on either a standard chow or high-fat diet (HFD), […]

Introduction and Objective: Intermittent energy restriction (IER) and time-restricted eating (TRE) are two forms of intermittent fasting that may reduce diabetes medication needs in type 2 diabetes (T2D). However, head-to-head comparisons of IF approaches and trials using IF in T2D remain limited. We evaluated diabetes remission and pharmacologic de-intensification in a secondary analysis of a […]

Introduction and Objective: A convergence of dysregulated metabolic, polygenic and environmental factors drives the pathophysiology of diabetes mellitus. We performed unsupervised integration of transcriptomic and metabolomic data among participants in the Rare and Atypical Diabetes Network (RADIANT) to identify distinct endotypes of atypical diabetes.Methods: This cross-sectional, observational study included RADIANT participants meeting predefined atypical diabetes […]

Introduction and Objective: Older adults with pre-diabetes or type 2 diabetes experience hospitalization and bed rest more frequently than healthy older adults. However, the impact of physical inactivity induced by bed rest on insulin sensitivity in older adults with pre- or type 2 diabetes is unknown. To address this, we conducted a 10-day bed rest […]

Introduction and Objective: The AABBCC approach (Age <35 years, Autoimmunity [family or personal history], BMI <25 kg/m2, Background, Control [not responding to oral agents], and Comorbidities) has been proposed by the American Diabetes Association to help distinguish between diabetes types. This study examined the reclassification rates from prediabetes or type 2 diabetes (T2D) to type […]

Introduction and Objective: Suboptimal diabetes medication adherence disproportionately affects Latino adults with type 2 diabetes (T2D). REACH is a text messaging platform based on the Information-Motivation-Behavioral skills model that addresses barriers to medication adherence. REACH was adapted into Spanish (REACH-Español) and is being evaluated in a 6-month pilot RCT among 70 Latino adults with T2D. […]

Introduction and Objective: Maturity Onset Diabetes of the Young (MODY) is an underrecognized and misdiagnosed form of diabetes that refers to a group of single gene causes of diabetes with a strong autosomal dominant inheritance. Fourteen (14) gene mutations have been identified accounting for 1-5% of all diabetes cases. Identification of MODY is necessary for […]

Introduction and Objective: Chronic opioid use is associated with high risk of overdose and developing substance use disorder. GLP-1RAs may influence reward-related neurobehavioral pathways, however, their real-world effects on opioid-related outcomes are unclear. We evaluated the association between GLP-1RA use and risk of opioid overdose among individuals with chronic opioid use.Methods: Using US claims data, […]

Introduction and Objective: The C-reactive protein-triglyceride-glucose index (CTI) is a composite biomarker reflecting insulin resistance and systemic inflammation. Large-scale evidence linking CTI to multiple chronic diseases and cause-specific mortality remains limited.Methods: We conducted a multicenter cohort study of middle-aged and older adults using the China Health and Retirement Longitudinal Study (CHARLS, n=5366) and US National […]