Introduction Therapeutic inertia (failure to initiate or intensify therapy when therapeutic goals are unmet) contributes to poor glycemic control and diabetes-related complications. We assessed the extent of therapeutic inertia, defined as a lack of new prescription orders for sodium-glucose cotransporter-2 inhibitors (SGLT2i) or glucagon-like peptide-1 receptor agonists (GLP-1RA), among patients with type 2 diabetes and […]
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How Long Can Poop Stay in Your Body Before It Impacts Your Health?
Share on PinterestThe time it takes for stool to transit through your body can affect your health. Image Credit: AUDSHULE/Stocksy Research suggests that the amount of time stool spends in your body may affect your overall health. This may be due to changes in gut microbiomes associated with how quickly or slowly stool moves through […]
Read MoreDifferences in association between gestational weight gain and perinatal outcomes according to pre-pregnancy body mass index categories and gestational diabetes mellitus status: findings from a large Japanese cohort
Introduction We aimed to examine the impact of gestational weight gain (GWG) on perinatal outcomes based on body mass index (BMI) category and gestational diabetes mellitus (GDM) status. Research design and methods This retrospective study included 53 183 Japanese women with GDM and 734 028 with normal glucose tolerance (NGT). We assessed interaction effects of […]
Read MoreFeasibility of using OGTT 1-h PG as a diagnostic criterion for diabetes and pre-diabetes
Aims To investigate whether oral glucose tolerance test (OGTT) 1-hour plasma glucose (1-h PG) concentration can be used as the criterion for diagnosing diabetes mellitus (DM) and pre-diabetes. Materials and methods Data were collected from 1021 outpatients who completed a 5-point OGTT. The 2 test was used to compare the prevalence of diabetes and pre-diabetes […]
Read MoreSex differences in glycemic outcomes: a systematic review and meta-analysis of diabetes treatments
Sex differences in glycemic outcomes following insulin therapy remain underexplored despite biological and psychosocial factors that may influence individual responses. This systematic review examines sex-specific differences in glycemic control to guide personalized diabetes care and promote health equity. We searched PubMed, Scopus, Cochrane Library, and Google Scholar (August 2014–December 2025) for randomized and observational studies […]
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Could an Avocado and Mango a Day Keep High Blood Pressure at Bay?
Share on PinterestA recent study suggests a daily avocado-mango combo may offer heart health benefits, such as lowering blood pressure. Nadine Greeff/Stocksy Eating one avocado and 1 cup of mango daily may improve blood vessel function in as little as 8 weeks, according to new research. The avocado-mango combo was linked to better flow-mediated dilation […]
Read MoreBiallelic Pathogenic Variants in IL2RA Cause Neonatal-Onset Monogenic Autoimmune Diabetes
Autoimmune diabetes presenting in infancy or with additional autoimmune disorders can be the result of highly penetrant variants in key immune homeostasis genes. An example of this is observed with biallelic pathogenic variants in IL2RA (CD25), which causes immunodeficiency 41 (IMD41). IL2RA encodes the α-chain of the interleukin-2 receptor, which helps regulate the growth and […]
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Is Your Sleep App Helping or Just Stressing You Out?
Share on PinterestResearch shows that using sleep apps may increase stress in people with insomnia. Image Credit: janiecbros/Getty Images A recent study has found that the use of sleep apps may lead to negative effects in people with insomnia. The researchers also note that sleep apps may not give an accurate image of your sleep. […]
Read MoreEffects of Pancreatic Resection on Liver Fat Content and Amino Acid, Lipid, and Glucose Metabolism: A Prospective 1-Year Follow-up Study
Individuals who undergo pancreatic resection are at increased risk of developing hepatic steatosis. Glucagon is a key regulator of hepatic glucose, amino acids, and lipid metabolism, and the change in circulating glucagon is suggested to contribute to the pathogenesis of postoperative steatotic liver disease. Here, we aimed to elucidate hepatic and metabolic changes induced by […]
Read MoreANGPTL4 Induces Aberrant Lymphatic-Like Remodeling in Proliferative Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of vision loss in working-age adults and often progresses to proliferative diabetic retinopathy (PDR) with irreversible complications. Anti–vascular endothelial growth factor (VEGF) therapy remains the first-line treatment; however, resistance poses a significant challenge, necessitating alternative therapeutic targets. This study explores the role of angiopoietin-like protein 4 (ANGPTL4) in […]
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