Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the role of ubiquitin specific peptidase 2 (USP2), a key regulator of insulin resistance, in sarcopenia remains unclear. Peroxisome proliferator–activated receptor γ (PPAR-γ) plays a critical role in regulating muscle atrophy. The role of deubiquitinase USP2 in mitigating muscle […]
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Incidence of metabolic and bariatric surgery among US adults with obesity by diabetes status: 2016–2020
Discussion From 2016 to 2020, over 900 000 MBS procedures were performed in inpatient and hospital-owned ambulatory surgical centers in the USA. For adults with or without diabetes, women and persons with class III obesity had a significantly higher incidence of MBS. Adults with obesity and diabetes had nearly threefold higher age- and sex-adjusted incidence of […]
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Exercise Lowers Death Risk by 60% in Cancer Survivors
Share on PinterestModerate daily exercise significantly reduced the risk of death from cardiovascular disease among female cancer survivors, a new study found SolStock/Getty Images Among older female cancer survivors, moderate daily exercise significantly reduced the risk of death from cardiovascular disease. Cancer survivors are statistically more likely to develop cardiovascular disease. Reducing sedentary time and […]
Read MoreDiabetes Core Update November 2024
Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreAtf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
Glucolipotoxicity, caused by combined hyperglycemia and hyperlipidemia, results in β-cell failure and type 2 diabetes via cellular stress-related mechanisms. Activating transcription factor 4 (Atf4) is an essential effector of stress response. We show here that Atf4 expression in β-cells is minimally required for glucose homeostasis in juvenile and adolescent mice but it is needed for […]
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Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes
Discussion This high-throughput proteomics approach identified a three-protein signature, namely CDCP1, SIRT2 and LEPR, significantly associated with baseline CES-D score and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes. The positive association of CDCP1 and SIRT2 and the inverse association of LEPR with baseline and persistent/recurrent depressive symptoms were independent of confounding […]
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Vaginal Infection Affecting 1 in 3 Women Is Really an STI, Study Finds
Share on PinterestBacterial vaginosis (BV) is not classified as a sexually transmitted infection, but the results of a new study could change that. ljubaphoto/Getty Images New research suggests a common vaginal infection may actually be a sexually transmitted infection. Researchers say bacterial vaginosis (BV) also occurs in males despite being often viewed as a condition […]
Read MoreDiabetes Core Update : Special Episode- Residual Risk
In this special episode on Residual Risk: A Focus on Triglycerides, our host, Dr. Neil Skolnik will discuss Residual Risk, Triglycerides and how to reduce residual risk with Dr. Christie Ballantyne, Director of the Center for Cardiometabolic Disease Prevention, Baylor College of Medicine. Based on popular demand this episode, originally aired in August 2023, is […]
Read MoreLrtm1: A Novel Sensor of Insulin Signaling and Regulator of Metabolism and Activity
Insulin regulates glucose uptake and metabolism in muscle via the insulin receptor. Here, we show that Lrtm1 (leucine-rich repeat and transmembrane domain 1), a protein of unknown function enriched in insulin-responsive metabolic tissues, senses changes in insulin signaling in muscle and serves as a regulator of metabolic response. Thus, whole-body Lrtm1-deficient mice exhibit a reduced […]
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Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes
Baseline characteristics Anthropometric data of both groups were comparable except for nominally higher percentage of females and higher high-density lipoprotein-cholesterol in the COVID-neg group (table 1). Table 1 View inline•Open as popup Participants’ characteristics at baseline Follow-up after COVID-19 None of the participants of the COVID-pos group had severe COVID-19 according to the classification by […]
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