Share on PinterestThe 75 Medium challenge may help people build healthy, sustainable habits that lead to weight loss and improved fitness. Getty Images 75 Medium is a new trend that’s gaining popularity on social media platforms like TikTok. It’s designed as a more sustainable alternative to the 75 Hard challenge. It includes daily movement, flexible […]
Read MoreEarly postprandial glucagon concentrations are higher in type 1 diabetes (T1D) than in individuals with no diabetes (ND). To determine the cause, we infused stable [13C9, 15N1]glucagon before, during, and after a mixed meal in 16 ND and 16 T1D individuals to measure glucagon turnover. In a subcohort of 9 ND and 12 T1D individuals, […]
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Share on PinterestMany children’s medical offices and state health departments aren’t in compliance with the CDC’s new child vaccine guidelines. Robert Michael/picture alliance via Getty Images Pediatric medical professionals are pushing back against new CDC recommendations that implemented major changes to the childhood immunization schedule. Many pediatricians rely on advice from the American Academy of […]
Read MorePreclinical studies suggest that activating branched-chain amino acid (BCAA) catabolism may improve chronic kidney disease (CKD). In this prospective clinical study, we sought to examine the association between urinary BCAA excretion and risk of CKD progression in patients with type 2 diabetes. Baseline urinary BCAAs were measured by mass spectrometry in 1,868 outpatients with type […]
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Share on PinterestThe United States recorded a 33-year high in measles cases in 2025, the highest level of U.S. measles cases since 1992.Jan Sonnenmair/Getty Images The United States is at risk of losing its measles elimination status, which it has held since 2000. The designation may be revoked because in 2025, the U.S. experienced its […]
Read MoreB lymphocytes are thought to drive β-cell destruction in type 1 diabetes (T1D) by activating anti-islet T cells. However, the observation that autoreactive T-cell activation and disease progression can occur without B cells challenges this view. Still, preclinical and clinical studies have shown that B-cell depletion alleviates β-cell destruction, suggesting a critical role for B […]
Read MoreMaturity-onset diabetes of the young (MODY) can present after the age of 40 years, but its prevalence and clinical characteristics, and the utility of simple clinical features for selecting cases in this age group, remain poorly defined. We analyzed whole-exome and clinical data from 51,619 individuals with diabetes diagnosed after age 40 years from one […]
Read MoreWe used a dual (intravenous and oral) glucose tracer protocol to evaluate rates of glucose appearance in the circulation, insulin-mediated glucose disposal (IMGD), and noninsulin-mediated glucose disposal (NIMGD) for 4 h after consumption of a mixed meal in people with obesity and type 2 diabetes before and after marked (∼20%) weight loss, induced by behavioral […]
Read MoreMetabolic dysfunction–associated steatotic liver disease (MASLD) has emerged as a global epidemic, yet its underlying molecular mechanisms remain elusive, and therapeutic options are limited. The interorgan communication between liver and adipose tissue plays a crucial role in maintaining hepatic lipid homeostasis. This study investigates the role of G-protein–coupled bile acid receptor 1 (TGR5) in adipose […]
Read MorePancreatic fibrosis has been proposed as a contributor to type 2 diabetes (T2D) by impairing islet function, but whether it plays a causal role remains unclear. We investigated this question using two complementary approaches. First, we performed a computed tomography–based retrospective case-control study (T2D case patients: n = 58; control participants: n = 58) assessing […]
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