Introduction and Objective: The role of maternal lipids, especially triglycerides (TG), in contributing to excess fetal fat accretion in pregnancies affected by obesity or diabetes is of increasing interest, given supportive data in obesity. Outside of pregnancy, fasting TG (FTG) are reported as higher on Mondays, after the weekend. No such data exists in pregnancy. […]
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Heart Attack Deaths Decline in U.S., but Other Heart Issues Are Increa
Share on PinterestHeart disease overall has decreased by 66% since 1970, but it remains the leading cause of death among Americans. Tashdique Mehtaj Ahmed/Getty Images Heart attacks have become more survivable in the past 50 years, and are no longer the leading cause of heart disease-related deaths, a new study reports. As heart attack deaths […]
Read More924-P: Predictors of Diabetes-Related Distress following Closed-Loop Initiation in Adults with Type 1 Diabetes in the UK—Insights from the Association of British Clinical Diabetologists
Introduction and Objective: The National Health Service (NHS) England hybrid closed-loop (HCL) pilot provided access to HCL for adults with type 1 diabetes (T1D), managed with an insulin pump and intermittently scanned continuous glucose monitoring, with a HbA1c ≥8.5%. We assessed the factors associated with improved diabetes-related distress (DRD) at follow up.Methods: Anonymized baseline and […]
Read More332-OR: Social Isolation and Loneliness and Stroke Risk in Men and Women with Diabetes
Introduction and Objective: We evaluated the association between social isolation, loneliness, and stroke risk in individuals with diabetes (DM) (vs. euglycemia) and assessed sex differences in the association.Methods: We included participants with DM (N=40,684) (defined by self-reported DM diagnosis, DM medication, HbA1c>6.5%, ICD codes) and sex-, race-, age-, and center-matched euglycemic individuals (1:1) from the […]
Read More923-P: Fasting Experience, Glycemic Control, and Fear of Hypoglycemia in People with Type 1 Diabetes Using Open-Source vs. Commercial Automated Insulin Delivery during Ramadan—A Multicenter Study from Saudi Arabia
Introduction and Objective: Open-source automated insulin delivery (OS-AID) has been shown to improve glycemic control in people with type 1 diabetes (PWT1D). We compare the effectiveness, safety, and fear of hypoglycemia (FOH) between OS-AID and commercial (C-AID) systems during Ramadan fasting.Methods: We recruited 114 PWT1D fasting during Ramadan 2024 using an AID system [OS-AID (n=7) […]
Read More653-P: Psychosocial Factors and Technology Perceptions Are Associated with Glycemic Outcomes in Fully Closed Loop Systems (FCL)
Introduction and Objective: To evaluate the impact of psychosocial factors, as assessed by the INSPIRE Questionnaire, and perceptions of technology efficacy (TES metrics) on glycemic outcomes and user acceptance of FCL systems in adults with type 1 diabetes.Methods: Data were analyzed from a cohort of 12 adults with T1D who participated in a 1-week at […]
Read More922-P: Fear of Hypoglycemia after Ramadan Fasting among People with Type 1 Diabetes—A Multicenter Study from Saudi Arabia
Introduction and Objective: Intermittent fasting, including Ramadan fasting, increases the risk of hypoglycemia in people with type 1 diabetes (PWT1D). We examined the prevalence and predictors of fear of hypoglycemia (FOH) after Ramadan in PWT1D who attempted to fast.Methods: Fasting experience, glycemic control, and FOH were evaluated in 159 PWT1D who attempted to fast Ramadan […]
Read More250-OR: Cytokines Differentially Alter Tight Junctional Proteins to Increase Retinal Microvascular Endothelial Cell Permeability
Introduction and Objective: Inflammation is associated with progression of diabetic retinopathy (DR). Inflammatory cytokines tumor necrosis factor alpha (TNFα), interleukin-1β (IL-1β), and interleukin-6 (IL-6) are elevated in DR and trigger retinal microvascular leakage. RMEC tight junction complexes include the transmembrane proteins occludin and ZO-1. Diabetic relevant stimuli cause changes in occludin and ZO-1 localization and […]
Read More921-P: Impact of Heart Rate and Step Count on Deep Learning Glucose Prediction Models during Physical Activity
Introduction and Objective: Accurate glucose prediction is vital for effective glucose management during physical activity (PA) [1], as PA significantly impacts glucose dynamics. This study evaluates the integration of heart rate (HR) and step count per minute (SCPM) data into deep learning (DL)-based glucose prediction models.Methods: The T1DEXI dataset [2] was used (561 T1D adults […]
Read More1651-P: Lactate Is Associated with Established Markers of Metabolic Dysfunction in Late Pregnancy
Introduction and Objective: The utility of lactate as an indicator of metabolic dysfunction during pregnancy is unknown. This study determined if blood lactate is related to established markers of metabolic dysfunction (insulin resistance, obesity, substrate oxidation) in pregnancy. Methods: Respiratory quotient (RQ) and blood was collected before and serially after a high-fat meal. Glucose and […]
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