Author: sugaradmin

Introduction and Objective: We introduce a heavy water (2H2 O) labeling technique to measure fluxes across a metabolome. The principle is that metabolic pathways comprise enzymatic reactions that exchange hydrogen between solvent water and covalent C-H bonds.Methods: The number (n) of exchangeable C-H sites is calculated from combinatorial probabilities (isotope ratios) after 2H2 O labeling, […]

Introduction and Objective: The SECURE-T2D pivotal trial recently demonstrated safety and efficacy of the Omnipod® 5 Automated Insulin Delivery (AID) System in adults with insulin-treated T2D. This sub-analysis evaluated outcomes in participants previously using basal without bolus insulin.Methods: This multicenter 305-participant single-arm trial enrolled 63 participants with T2D using basal without bolus insulin (mean age […]

Introduction and Objective: Asian Indians have increased insulin resistance, more rapid β-cell decline & higher T2D risk. Early interventions targeting these factors can prevent T2D. We compared the effects of a low carbohydrate, low saturated fat (LC) diet to a high unrefined carbohydrate, low fat (HC) diet on β-cell function, insulin sensitivity & fat distribution […]

Introduction and Objective: Bone fragility is a recognized complication of T1D, with previous studies reporting conflicting associations with glycemia. We aimed to evaluate BMD and to identify factors associated with BMD in youth with T1D.Methods: This cross-sectional analysis included youth aged 8-17 years with T1D for ≥1 years. Total body less head (TBLH) BMD was […]

Introduction and Objective: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver disease linked to obesity and metabolic disorders. Caloric restriction (CR) and intermittent fasting (IF) improve metabolic health, but their effects on MAFLD and underlying mechanisms are unclear. This study compared CR and IF regimens in MAFLD models and explored the role […]

Introduction and Objective: Efforts to improve influenza vaccination rates among patients with diabetes can be enhanced with accurate documentation of vaccination status in the electronic medical record (EMR). This quality improvement project aimed to identify factors contributing to inaccurate vaccination status in the EMR documentation.Methods: Ambulatory patients with diabetes presenting for routine follow up were […]

Introduction and Objective: Exendin-4 (Ex-4) is a glucagon-like peptide-1 receptor agonist used for the treatment of type 2 diabetes and other metabolic disorders, including steatotic liver disease. However, its short half-life necessitates multiple daily injections, resulting in poor patient compliance, limited efficacy, and increased treatment costs. To address this problem, we introduce a novel drug […]

Introduction and Objective: Introduction & Objective: Small fiber neuropathy (SFN) is known to develop early in the course of diabetic polyneuropathy (DPN). It has been shown that single nucleotide polymorphisms (SNPs) are involved in DPN, but how SNPs correlate with SFN has not yet been investigated. In the present study, we explored the correlation in […]

Introduction and Objective: Hypercaloric nutrition may sequentially promote insulin resistance across tissues. Recent rodent studies indicate white adipose tissue (WAT) as key driver of whole-body insulin resistance. Thus, we hypothesized that WAT may respond early to overnutrition-induced metabolic changes in humans.Methods: In a randomized, parallel-group study, young glucose tolerant volunteers consumed either an isocaloric (ID; […]

Introduction and Objective: Painful diabetic neuropathy (DN) is a common and challenging complication of diabetes with limited treatments. Our research reveals that treatment responders show enhanced connectivity between the insula and corticolimbic systems, modulated by dopamine and opioid receptors. These findings highlight potential mechanisms of treatment efficacy and pathways for novel therapeutic development.Methods: 43 participants […]