Through her parents, Dawn Davis was exposed to opposite ends of the medical field. Her mother worked and volunteered with community and health–related nonprofits. Her father was an engineer developing pacemakers and MRI machines. “I remember a prototype pacemaker at home, encased in liquid plastic,” Davis says, “and I was probably one of the first […]
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Response to From Systemic B-Cell Targeting to Local Immune Engineering in Islet Transplantation
We appreciate the thoughtful commentary from Zhu et al. (1) regarding our study on B lymphocytes and regulatory T cells (Tregs) in type 1 diabetes and islet transplantation (2). We are pleased that they highlight our central observations in the NOD background, including the ability of B-cell deficiency to permit anti-CD45RB–mediated tolerance in the autoimmune type […]
Read MorePericytes Are Not Merely Accessory Cells in Pancreatic Islets
JDRF (Breakthrough T1D)3-PDF-2024-1503-A-NNIH RO1DK133483 and DK138471 Source link
Read MoreFrom Systemic B-Cell Targeting to Local Immune Engineering in Islet Transplantation
We read with great interest the recent study by Wilson et al. (1), which demonstrated that B lymphocytes impair regulatory T cell (Treg) development and function, thereby eroding islet tolerance in the NOD islet allograft model. Their findings show that B-cell deficiency enables durable graft acceptance following short course anti-CD45RB treatment, accompanied by Helios+ Treg expansion, improved […]
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Heart Health Benefits Fade After Stopping GLP-1 Drugs
Share on PinterestStopping GLP-1s can quickly reverse the cardiovascular benefits gained while taking them. Image Credit: the_burtons/Getty Images A recent study found that stopping GLP-1s, such as Ozempic or Wegovy, can reverse the cardiovascular benefits they provide. The findings show that stopping the medications for as little as 6 months raises the risk of heart […]
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New Guidelines Say Keep It Simple for Best Results
Share on PinterestNew resistance training recommendations emphasize consistency over complexity. Image Credit: Westend61/Getty Images You don’t need a perfect workout plan to benefit from strength training, according to new recommendations from the American College of Sports Medicine. A large new review finds that at-home workouts or body weight exercises can be just as effective as […]
Read MoreAfrican immigrants with type 2 diabetes present with three physiologic subtypes: implications for screening, diagnosis and treatment
Introduction As type 2 diabetes (T2D) prevalence increases in the USA and Africa, factors from both regions affect African immigrants. Objective T2D in African immigrants was characterized by examining: (a) insulin deficiency and insulin resistance; (b) phenotypic presentation; (c) sociodemographic factors. Methods In 633 African immigrants (male: 62%, age 39±11, (mean±SD), range 20–70 years), body […]
Read MoreAssociation of GLP-1 receptor agonists with intentional self-harm in patients with type 2 diabetes: a Sentinel Distributed Database study
Introduction The U.S. Food and Drug Administration (FDA) investigated the potential risk of suicidal ideation and behaviors for glucagon-like peptide 1 receptor agonists (GLP-1 RAs) on learning of post-marketing reports of suicidal ideation and behaviors in patients taking GLP-1 RAs. This study assessed a potential association with intentional self-harm comparing GLP-1 RAs to other antidiabetic […]
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Hospital Worker Had 3 Attacks in 4 Days. This May Have Saved His Life
Share on PinterestPatient transporter Tommy Bell (pictured above) survived 3 heart attacks over 4 days, thanks to quick thinking — and care from colleagues at the hospital where he worked. Advent Health 62-year-old Tommy Bell survived three heart attacks in the span of four days. Bell received care at the same hospital where he has […]
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GLP-1s Can Help Lower Risk for Young Adults With Prediabetes
Share on PinterestNew research highlights a need for earlier, more tailored interventions to prevent type 2 diabetes in young adults with prediabetes. Klaus Vedfelt/Getty Images Researchers found that type 2 diabetes risk varies among adults ages 18 to 40. Those with high fasting glucose, especially if they qualified for GLP-1 treatment, had higher risk. These […]
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