Month: June 2026

Introduction and Objective: The impact of glycemic variability (GV) on muscle mass in Type 2 diabetes mellitus (T2DM) remains unclear under the updated Asian Working Group for Sarcopenia (AWGS) 2025 criteria. We investigated the association between continuous glucose monitoring (CGM)-derived GV and low skeletal muscle mass (LSMM).Methods: This cross-sectional study included 614 hospitalized T2DM patients […]

Introduction and Objective: KAT8 (lysine acetyltransferase 8), also known as MOF or MYST1, acetylates diverse protein substrates to regulate multiple cellular processes. Although KAT8 is expressed in adipocytes and adipose tissue, its function in adipocytes is unknown. We previously generated a mouse model with adiponectin-expressing cell-specific deletion of KAT8 (KAT8AKO) and found that these mice […]

Introduction and Objective: The risk of hypoglycemia increases with age and medical complexity. Recent trends in the epidemiology of hypoglycemia among older adults with diabetes have not been previously evaluated.Methods: We conducted an annual repeated cross-sectional cohort study from 2017-2024 in Epic Cosmos, a nationwide database of electronic health records of more than 300 million […]

Introduction and Objective: Innate immune signaling is a key driver of diabetic nephropathy (DN). We previously showed that diabetes-induced expression of the stress protein REDD1 contributes to proinflammatory signaling in podocytes. The objective of this study was to determine if therapeutic suppression of REDD1 in podocytes was sufficient to mitigate renal inflammation in diabetic mice.Methods: […]

Introduction and Objective: Calcium is a key regulator of insulin secretion; yet, regulation of mitochondrial calcium handling is understudied in pancreatic β-cells. Here, we assessed whether mitochondrial calcium (mtCa2+) overload by deletion of the mitochondrial sodium-calcium exchanger (NCLX) in β-cells is sufficient to perturb glucose homeostasis in vivo. Given that mitochondrial metabolic activity is calcium-dependent, […]

Introduction and Objective: GDF8 and activin A signal through the activin typeII receptor ActRIIA and ActRIIB to limit muscle growth. However, the specific role of each ActRII at regulating muscle mass remains to be elucidated. Here we pharmacologically interrogate the function of ActRIIA and ActRIIB using human myoblast differentiation model which is highly predictive of […]

Introduction and Objective: Immune-mediated rejection remains a major barrier to durable pancreatic islet transplantation for type 1 diabetes. Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory properties, and engineering MSCs to overexpress alpha-1 antitrypsin (AAT) may enhance their therapeutic potential. This study evaluated whether co-transplantation of human islets with AAT-overexpressing MSCs (AAT-MSCs) improves graft survival and modulates […]

Introduction and Objective: T1D-CATCH (Collaboration Around Technology using Community Health Workers) was a hybrid effectiveness-implementation randomized trial evaluating a 6-month CHW intervention to increase diabetes technology use among high-risk young adults with T1D. Co-designed with young adults and providers, the intervention aimed to reduce provider burden and deliver patient-centered technology support. This report focuses on […]

Introduction and Objective: Excessive diabetes device alerts can be burdensome for people with diabetes. Frequent autocorrection boluses inherent to the MiniMed™ 780G (MM780G) system are shown to reduce nighttime (SG) alarms/alerts.1 The present study assessed SG alarm/alert burden and glycemia in system users with and without optional SG alerts on.Methods: Deidentified CareLink™ data (01FEB2025 to […]

Introduction and Objective: Skeletal muscle plays a central role in whole-body lipid metabolism through mitochondrial and peroxisomal fatty acid oxidation (FAO). When skeletal muscle lipid metabolism is impaired, whole-body adaptations occur to maintain metabolic homeostasis. We hypothesized that limiting skeletal muscle lipid metabolism through mitochondria &/or peroxisomes would trigger adaptive responses to reduce dietary lipid […]