Introduction and Objective: Skeletal muscle plays a central role in whole-body lipid metabolism through mitochondrial and peroxisomal fatty acid oxidation (FAO). When skeletal muscle lipid metabolism is impaired, whole-body adaptations occur to maintain metabolic homeostasis. We hypothesized that limiting skeletal muscle lipid metabolism through mitochondria &/or peroxisomes would trigger adaptive responses to reduce dietary lipid […]
Read MoreMonth: June 2026
2677-P: Dynamic Epitranscriptomic Regulation across the Developing Human Pancreas
Introduction and Objective: RNA modifications are crucial regulators of gene expression in human development. They have an established role in regulating β cell development and function, with dysregulation resulting in diabetes. Numerous limitations have restricted the study of these modifications directly in pancreatic tissue. We utilize a cohort of human fetal pancreatic samples to determine […]
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Ozempic, Wegovy Linked to Reduced Violent Behavior, Impulsivity
Share on PinterestGLP-1s may help reduce impulsivity, alcohol intake, and violent behaviors in adults. Image Credit: munro/gettyimages A recent study found that GLP-1 medications like Ozempic and Wegovy may help lower impulsive and violent behaviors. The researchers noted that higher impulsivity and alcohol use were significantly associated with violent behavior overall, but were weaker among […]
Read More3047-LB: Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD) and Microvascular Complications in Hospitalized Patients with Type 2 Diabetes Mellitus (T2DM) in Almaty, Kazakhstan
Introduction and Objective: Despite its systemic impact, MASLD is often overlooked in routine T2DM care. Our study evaluates whether glycemic status and the NFS are associated with the prevalence and severity of microvascular complications in hospitalized patients with T2DM.Methods: Our retrospective cross-sectional study analyzed data from 4,009 hospitalized patients with T2DM in Almaty, Kazakhstan (2017-2019). […]
Read More1361-P: Recurrent Antecedent Intranasal Insulin Blunts the Epinephrine Response to Hypoglycemia
Introduction and Objective: Recurrent insulin-induced hypoglycemia blunts the counterregulatory response (CRR) to hypoglycemia. Since antecedent hyperinsulinemia coincides with antecedent hypoglycemia, it is possible that recurrent insulin administration per se could contribute to the pathophysiology of a blunted CRR. To target insulin delivery to the central nervous system, this study tested the hypothesis that recurrent intranasal […]
Read More1521-P: Effects of a Clinical Sports and Activity Program on Glycemic Control in Youth with Type 1 Diabetes
Introduction and Objective: Physical activity (PA) is important in type 1 diabetes (T1D) management. However, PA poses challenges as it can cause unpredictable changes in blood glucose (BG) levels. Key reasons include insulin-glucose mismatch, nutrition, type of activity, and individual variability. The Clinical Sports and Activity Program (CSAP) at the Wendy Novak Diabetes Institute educates […]
Read More2143-P: Peri- and Postnatal Psychosocial Health in Women with Type 1 Diabetes: The PROMISE Study
Introduction and Objective: Type 1 diabetes (T1D) increases the risk of depression. Pregnancy can be a particularly stressful time for women with T1D, but little is known about pregnancy-related psychosocial health in this population. We report on the prevalence of depressive symptoms and diabetes distress measured by validated surveys among pregnant and postpartum women participating […]
Read More3042-LB: Residence Time (RT) of Insulin and C-Peptide Reveals Reversible vs. Treatment-Resistant ß-Cell Dysfunction in Female ZDF rats (fZDF) on High-Fat Diet (HFD)
Introduction and Objective: β-cell secretory reserve declines prior to overt hyperglycemia but there are no direct clinical biomarkers. We asked whether shorter RT of insulin (Ins) or C-peptide (C-P) in β-cells before secretion non-invasively reveals reversibility of β-cell dysfunction in HFD-fed fZDF treated with rosiglitazone (Rosi).Methods: fZDF were on HFD or chow for 10, 20, […]
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Just 5 Minutes of Exercise Can Give Your Mood a Boost. Here’s How
Share on PinterestSmall amounts of physical activity, like everyday chores, can boost your mood and even count toward your exercise goals. Image Credit: Getty Images/Oleh_Slobodeniuk New research has found that as little as 5 to 10 minutes of physical activity can provide an immediate boost to both mood and energy. Exercise and everyday movement are […]
Read More2213-P: Islet Autoantibody Positivity Cutoff Does Not Vary by Ancestry in U.S. Population Supporting the Use of Single Cutoff across Population
Introduction and Objective: Accurate control population-based thresholds for Islet autoantibodies positivity are essential to diagnosed and predict type 1 diabetes (T1D). Most positivity thresholds come from European populations, and it remains unclear whether these thresholds differ across ancestries within the same country.Methods: We analyzed GADA, IA-2A and ZnT8A in 1543 diabetes-free adults (595 -European, 474 […]
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