Month: June 2026

Introduction and Objective: In the SURPASS-4 clinical trial in patients with type 2 diabetes (T2D) at high cardiovascular risk, once-weekly treatment with the dual GLP-1/GIP receptor agonist, tirzepatide (TZP) resulted in substantial weight reduction, slower kidney function decline, and reduced albuminuria compared to insulin glargine. This post-hoc analysis evaluated the effect of TZP on 52-week […]

Introduction and Objective: Body mass index (BMI) alone may miss obesity risk; ICMR-INDIAB study supports metabolic phenotyping into four groups based on their metabolic and BMI status: metabolically healthy non-obese (MHNO), metabolically obese non-obese (MONO), metabolically obese obese (MOO), and metabolically healthy obese (MHO). We assessed phenotype distribution and association with liver fibrosis stage using […]

Introduction and Objective: The rates of screening for metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis-4 (FIB-4) index is slowly increasing in the primary care setting. Access to Vibration-Controlled Transient Elastography (FibroScan) remains a barrier in identifying high-risk MASLD and is currently underutilized. We evaluate an approach to implementation of […]

Introduction and Objective: People with diabetes (PWD) who are beneficiaries of Medicaid have worse glycemic outcomes than those with private insurance and are at increased risk for poor clinical outcomes. Barriers to accessing automated insulin delivery (AID) systems include age, complex/extensive prior authorization policies, unclear documentation requirements, and healthcare provider implicit bias about who is […]

Introduction and Objective: Mobile app-based weight management programmes using artificial intelligence (AI) coaching are increasingly used to support lifestyle change in people with type 2 diabetes (T2D), but real-world outcomes remain limited. The aim of this study was to evaluate weight loss among adults with T2D using an AI-enabled weight management app, and to examine […]

Introduction and Objective: Insulin is secreted into the portal vein in response to nutrient ingestion. However, a significant proportion is extracted as it traverses the liver prior to reaching the systemic circulation. The effect of glucagon on hepatic extraction is uncertain. This is particularly germane to situations where postprandial suppression of glucagon is impaired, theoretically […]

Introduction and Objective: Gestational diabetes (GDM) and hypertensive disorders of pregnancy often co-occur and are the leading causes of maternal morbidity. We aimed to examine whether the risks of GDM and new-onset postpartum diabetes (PPDM) increase across gestational blood pressure (BP) categories following the current guidelines with lower thresholds for hypertension (systolic/diastolic BP ≥130/80 mmHg) […]

Introduction and Objective: The reduction of the insulin Fractional Clearance Rate (FCR) is an early marker of insulin resistance and/or beta-cell disfunction that may be observed before prediabetes arises. Here we aim to investigate whether such reduction is associated with easily measurable anthropometric characteristics, like body mass index (BMI), age and gender.Methods: We studied 204 […]

Introduction and Objective: Type 1 diabetes in adults is frequently misclassified as type 2, delaying appropriate insulin treatment and leading to worse outcomes. We developed a probability-based tool that combines pre-laboratory clinical characteristics and laboratory results to estimate the likelihood of type 1 vs. type 2 diabetes among adults with new-onset diabetes across four geographic […]

Introduction and Objective: There is a need for interventions that respond to cultural strengths and psychosocial burdens of underserved youth with diabetes and their families. Religion/spirituality is a resource that Latinx youth and their parents may use when other resources are unavailable. There is a gap in knowledge about the religious/spiritual experiences and needs of […]