Month: May 2026

Refractory chronic diabetic wounds severely threaten patient survival; however, current treatments do not adequately promote healing. Cathepsin K (CTSK), a collagen-degrading protease upregulated in early diabetic wounds, presents a potential therapeutic target, and human umbilical cord mesenchymal stem cell–derived extracellular vesicles (hUMSC-EVs) show promise in regeneration but are associated with challenges related to production yield […]

In their comment letter in this issue of Diabetes, Ragozzino et al. (1) raise several points regarding our recent publication (2) that “warrant further clarification to strengthen the translational impact of the work.” They indicate that “several mechanistic interpretations . . . are inferred from indirect behavioral and metabolic proxies,” mainly that “meal size and meal […]

National Institutes of HealthR01EY023397R01EY029693American Diabetes Association10.13039/100000041Grant Ref #11-22-IBSPM-12 Source link

“It was always sports,” Jonathan Campbell says, describing his childhood. He grew up in Toronto, where his father worked as a hydrogeologist and his mother as a grade school teacher. His initial interest was soccer, but by high school his focus had shifted entirely to basketball. “I spent a lot of time on a basketball […]

American Neuromuscular Foundation10.13039/100025799Mid-career Research Grant Source link

National Institute of Diabetes and Digestive and Kidney Diseases10.13039/100000062R01-DK123259 Source link

The study by Shah and Ayala (1) offers a valuable temporal dissection of semaglutide’s effects on feeding behavior, energy expenditure (EE), and substrate oxidation in obese mice. By distinguishing rapid, gradual, and maintenance phases of weight loss and extending observations into the posttreatment period, the authors provide a timely framework for understanding the evolving physiology […]

We read with interest the article by Uddin et al. (1) that was recently published in Diabetes. The authors present an in vivo imaging methodology using HYPOX-4 to visualize retinal hypoxia in early diabetes. This approach may help advance our understanding of diabetic retinopathy (DR) pathophysiology and aid in identifying preclinical biomarkers. Source link

Issues and Events Source link

In their recent article in Diabetes, Lin et al. (1) report an exceptionally strong correlation (r = −0.93) between insulin- and niacin-mediated suppression of FFA-palmitate Ra. Because these agents act through distinct proximal signaling pathways, this correlation, not only notable, is mechanistically constraining and directly informs the interpretation of adipose tissue (AT) dysfunction in obesity and […]