Aims To investigate whether oral glucose tolerance test (OGTT) 1-hour plasma glucose (1-h PG) concentration can be used as the criterion for diagnosing diabetes mellitus (DM) and pre-diabetes. Materials and methods Data were collected from 1021 outpatients who completed a 5-point OGTT. The 2 test was used to compare the prevalence of diabetes and pre-diabetes […]
Read MoreMonth: April 2026
Sex differences in glycemic outcomes: a systematic review and meta-analysis of diabetes treatments
Sex differences in glycemic outcomes following insulin therapy remain underexplored despite biological and psychosocial factors that may influence individual responses. This systematic review examines sex-specific differences in glycemic control to guide personalized diabetes care and promote health equity. We searched PubMed, Scopus, Cochrane Library, and Google Scholar (August 2014–December 2025) for randomized and observational studies […]
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Could an Avocado and Mango a Day Keep High Blood Pressure at Bay?
Share on PinterestA recent study suggests a daily avocado-mango combo may offer heart health benefits, such as lowering blood pressure. Nadine Greeff/Stocksy Eating one avocado and 1 cup of mango daily may improve blood vessel function in as little as 8 weeks, according to new research. The avocado-mango combo was linked to better flow-mediated dilation […]
Read MoreBiallelic Pathogenic Variants in IL2RA Cause Neonatal-Onset Monogenic Autoimmune Diabetes
Autoimmune diabetes presenting in infancy or with additional autoimmune disorders can be the result of highly penetrant variants in key immune homeostasis genes. An example of this is observed with biallelic pathogenic variants in IL2RA (CD25), which causes immunodeficiency 41 (IMD41). IL2RA encodes the α-chain of the interleukin-2 receptor, which helps regulate the growth and […]
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Is Your Sleep App Helping or Just Stressing You Out?
Share on PinterestResearch shows that using sleep apps may increase stress in people with insomnia. Image Credit: janiecbros/Getty Images A recent study has found that the use of sleep apps may lead to negative effects in people with insomnia. The researchers also note that sleep apps may not give an accurate image of your sleep. […]
Read MoreEffects of Pancreatic Resection on Liver Fat Content and Amino Acid, Lipid, and Glucose Metabolism: A Prospective 1-Year Follow-up Study
Individuals who undergo pancreatic resection are at increased risk of developing hepatic steatosis. Glucagon is a key regulator of hepatic glucose, amino acids, and lipid metabolism, and the change in circulating glucagon is suggested to contribute to the pathogenesis of postoperative steatotic liver disease. Here, we aimed to elucidate hepatic and metabolic changes induced by […]
Read MoreANGPTL4 Induces Aberrant Lymphatic-Like Remodeling in Proliferative Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of vision loss in working-age adults and often progresses to proliferative diabetic retinopathy (PDR) with irreversible complications. Anti–vascular endothelial growth factor (VEGF) therapy remains the first-line treatment; however, resistance poses a significant challenge, necessitating alternative therapeutic targets. This study explores the role of angiopoietin-like protein 4 (ANGPTL4) in […]
Read MoreNormalization of Insulin Resistance Rather Than Hyperglycemia Before Stroke Improves Functional Outcomes in a Mouse Model of Type 2 Diabetes
Prestroke hyperglycemia and insulin resistance (IR) independently correlate with poor stroke outcomes in type 2 diabetes (T2D), although their causative effect is undetermined. Interestingly, an increasing body of evidence points toward the importance of IR in determining stroke outcomes. Filling this gap is fundamental to identifying effective anti-T2D strategies to improve stroke prognosis in people […]
Read MoreMesenchymal Stem Cell and Secretome Treatments Inhibit the mTOR–NOX4 Pathway in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a major complication of diabetes characterized by progressive renal dysfunction driven by oxidative stress and inflammation involving mammalian target of rapamycin (mTOR) and NADPH oxidase (NOX) pathways. Mesenchymal stem cells (MSCs) have gained attention for their regenerative and immunomodulatory properties in attenuating DKD, but the mechanisms behind their protective effects […]
Read MoreQuantitative β-Cell Mass Imaging Redefines Disease Staging and Glycemic Control in Type 1 Diabetes
Noninvasive measurement of pancreatic β-cell mass remains an important unmet need in type 1 diabetes because conventional surrogate markers, such as C-peptide, often lack sensitivity in advanced disease. This study evaluated the glucagon-like peptide 1 receptor–targeted positron emission tomography tracer, 18F-labeled exendin-4–based probe conjugated with polyethylene glycol, [18F]FB(ePEG12)12-exendin-4 (18F-exendin-4), to determine its ability to visualize […]
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