Share on PinterestNew research suggests that GLP-1s could offer dual benefits for treating both metabolic and mental health issues. Catherine Falls Commercial/Getty Images A new study found that people taking GLP-1 drugs like Ozempic and Wegovy had a lower risk of worsening depression and anxiety. The participants also had fewer hospitalizations and required less sick […]
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Share on PinterestA new study suggests that people who eat more ultra-processed foods have poorer bone health. Sibila and Pavel/Stocksy Eating higher amounts of ultra-processed foods is associated with lower bone mineral density, even in younger adults under 65. Researchers also found that high ultra-processed food intake increases the risk of hip fractures. Experts say […]
Read MoreDiabetic corneal neuropathy (DCN) and diabetic retinopathy (DR) are microvascular complications and share common pathophysiological mechanisms. However, the relationship between them remains poorly defined. In this cross-sectional study, we aimed to investigate the association among DCN, DR, and tear mediators in 1,654 eyes from 822 participants, comprising 634 patients with type 2 diabetes and 188 […]
Read MoreAlternative splicing is an essential mechanism for generating protein diversity by producing distinct isoforms from a single gene. Dysregulation of splicing that affects pancreatic function and immune tolerance has been linked to both types 1 and 2 diabetes. Next-generation sequencing technologies, with their short read lengths, are limited in their ability to accurately detect splice […]
Read MoreGlucagon-like peptide 1 (GLP-1) receptor agonists improve dyslipidemia and reduce cardiovascular risk in type 2 diabetes (T2D), but the role of endogenous GLP-1 in lipid metabolism remains unclear. We evaluated the effect of dipeptidyl peptidase 4 (DPP-4) inhibition on the response of plasma triglycerides (TGs) to intraduodenal lipid and a mixed meal, and the impact […]
Read MoreIn the article cited above, affiliation Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain, was inadvertently omitted at submission for author SebastiáAlcover. Source link
Read MoreIn the article cited above, affiliation School of Biomedical Sciences, Ulster University, Coleraine, U.K., was inadvertently omitted at submission for author Andrei I. Tarosov. Source link
Read MoreEnteroviruses (EVs) have long been implicated in the development of islet autoimmunity (IA) and type 1 diabetes. However, given the ubiquity of EV infections in children, disease susceptibility is likely driven by host-specific immune responses rather than viral exposure alone. To investigate the host antibody response to EVs, we used virome-wide serological profiling (VirScan) to […]
Read MoreSkeletal muscle glucose transporter 4 (GLUT4) translocation to the plasma membrane determines glucose uptake in response to insulin and exercise and is disrupted in insulin resistance, making its experimental measurement critical. Confocal light microscopy is widely used for this purpose because of its ability to provide quantitative, high-resolution spatial information from small tissue amounts. However, […]
Read MoreAdipose tissue (AT) lipolysis insulin resistance results in excess free fatty acid (FFA) release. We tested the hypothesis that the ability of insulin to suppress AT lipolysis is unrelated to the ability of niacin to suppress lipolysis, because niacin acts through a different proximal signaling pathway. Ten volunteers (5 women and 5 men) with upper-body […]
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