Month: July 2025

Introduction and Objective: Diabetes mellitus is a common complication after solid organ transplant (SOT). Sodium-glucose cotransporter inhibitors (SGLT2i) have shown significant cardio-renal benefits in people with type 2 diabetes. However, their use in SOT recipients remains underexplored in the existing literature. We aimed to perform a systematic review and meta-analysis to evaluate the efficacy and […]

Introduction and Objective: This study examines the impact of online, virtual patient simulation (VPS)-based continuing medical education (CME) on performance related to diagnosis and management of T2D by diabetologists/endocrinologists (D/Es) and primary care physicians (PCPs).Methods: Intervention was 2 patient scenarios presenting in a VPS. Clinical guidance (CG) based on evidence was provided following each decision, […]

Introduction and Objective: Ketones are energy substrates, serving as a “superfuel” for the heart, skeletal muscle, etc.. Our previous work showed that 3-hour intravenous (IV) exogenous ketones (KE) improved left ventricular function in T2D patients with HFrEF by up to 6%, dose-dependently. However, IV delivery is invasive and impractical for daily use. This study explores […]

Introduction and Objective: Type 2 diabetes (T2D) is marked by impaired insulin secretion and action in metabolic organs like adipose tissue and skeletal muscle. Aberrant gene expression contributes to T2D. Alternative polyadenylation (APA) alters gene expression by producing mRNA isoforms with variable 3’ UTR lengths. The 3’ UTR interacts with trans-factors, affecting mRNA stability, translation, […]

Introduction and Objective: Proximal Intestinal Mucosal Ablation (PIMA) is a new endoscopic procedure to treat type 2 diabetes (T2D). PIMA replicates the metabolic benefits of gastric bypass surgery by ablating up to 75 cm of the post-ampullary intestinal mucosa with radiofrequency vapor ablation (RFVA). Similar technologies, limited to 15cm of duodenal mucosa, have attempted to […]

Introduction and Objective: Type 2 diabetes (T2D) is frequently associated with hepatic complications like fatty liver and fibrosis named Metabolic dysfunction associated steatotic liver disease (MASLD).This study evaluates the demographic profile, Body Mass Index (BMI) and liver health parameters— Fibrosis-4 (FIB-4) score, Controlled Attenuation Parameter (CAP) score and Liver Stiffness Measurement (LSM)Methods: A total of […]

Introduction and Objective: MET-233 is an ultra-long acting (ULA) amylin analog being evaluated in clinical trials for the treatment of obesity. We sought preclinical proof of concept that MET-233, designed to be combined with GLP-1R agonist MET-097, is an effective candidate for obesity treatment.Methods: MET-233 emerged from an amylin analog development program focused on potency, […]

Introduction and Objective: This study evaluated the prevalence of food insecurity (FI) among adults with diabetes initiating continuous glucose monitoring (CGM) therapy compared to national averages and examined associations with gender, age, and glycemic outcomes.Methods: Fifty adults initiating CGM therapy were screened for FI using the USDA Six-Item Short Form. Individuals with an FI score […]

Introduction and Objective: A short-term study in obese T2D patients showed that the combination of dorzagliatin, a glucokinase activator (GKA) and sitagliptin improved glucose controls with increased GLP-1 secretion. This study aims to assess the impact of long-term administration of dorzagliatin and the combination of dorzagliatin/sitagliptin on glucose homeostasis in high-fat diet-induced obesity/diabetes (DIO) mice.Methods: […]

Introduction and Objective: CK-0045 is a novel long-acting IL-22 receptor agonist with great potential for treatment of patients with metabolic diseases based on preclinical data. Here we present the results of a randomized, double-blind, placebo-controlled, Phase 1 study investigating safety, tolerability, and pharmacokinetics of CK-0045 in healthy participants with and without obesity.Methods: A total of […]