Month: July 2025

Introduction and Objective: We investigated the role of insulin/IGF1 signaling in cardiac function and lifespan of MDKO mice (Irs1L/L•Irs2L/L•CreMck) generated by MCK (muscle creatine kinase) driven Cre expression in striated and cardiac muscle.Methods: MDKO mice died by 30 days of age with severe cardiomyopathy. Deletion of FoxO1 and FoxO3a in MDKO mice (MQKO mice) slowed […]

Introduction and Objective: GLP-1 and amylin peptide hormones independently reduce food intake, delay gastric emptying, and decrease glucagon release. Combination of GLP-1 and amylin analogs promotes greater weight loss and glycemic control than either agent alone. Here we assessed the in vivo efficacy of a novel oral amylin analog (VRB103) in rodent models, as well […]

Introduction and Objective: Wall shear stress (WSS), the force exerted by blood flow on vessel walls, is considered an early indicator of atherosclerosis, as moderate WSS supports endothelial function. It has been reported that WSS is associated with cerebral small vessel disease (SVD). Traditional methods like MRI and computational fluid dynamics assess WSS but are […]

Introduction and Objective: Black women in the U.S. women are disproportionately affected by type 2 diabetes. This disparity partly stems from gaps in clinical diabetes risk screening and education. Hair salons are community settings that are frequented by Black women and could offer unique opportunities to implement diabetes education and prediabetes screening in a trusted […]

Introduction and Objective: Insulin resistance (IR) significantly contributes to cardiovascular mortality in type 2 diabetes (T2D). Whether organ-specific IR (skeletal muscle, adipose tissue, liver) independently associates with structural and functional cardiac morbidity and mortality is unclear.Methods: This study included 850 Europeans with and 2243 without T2D of the LUdwigshafen RIsk and Cardiovascular Health (LURIC) cohort […]

Introduction and Objective: Epigenetic modifications, such as DNA methylation(DNAm), can provide a composite measurement of environmental/genetic influence on gene expression. A significant gap remains in defining DNAm profiles in diabetes, prior to DKD diagnosis. We determined blood-derived DNAm profiles, in type-2 diabetes(T2D) people with normal kidney function, that were predictive of DKD incidence in the […]

Introduction and Objective: Coronary artery calcium score (CACS) is an effective marker to stratify cardiovascular risk. Compared to type 2 diabetes (T2D) Ketosis Prone Diabetes (KPD) has an atypical presentation marked by ketosis during decompensation. We compared CACS and cardiovascular events (CVE) in KPD and T2D.Methods: It is a retrospective observational study (2014-2024) of KPD […]

Introduction and Objective: Weight management is essential for preventing type 2 diabetes, particularly in individuals with prediabetes. DNA methylation (DNAm) serves as a biomarker for capturing metabolic changes and disease progression. This study aimed to discover DNAm biomarkers linked to weight loss response in diabetes prevention interventions for individuals with prediabetes.Methods: We analyzed 168 subjects […]

Introduction and Objective: The Chinese diabetes guideline recommends a normal BMI as a component of comprehensive management of T2D. However, evidence on the independent or combined effects of glycemic control and normal BMI on long-term macrovascular outcomes is limited.Methods: Regional electronic health record data from Yinzhou Ningbo China (2006/1/1 – 2021/10/30) was used. Adult patients […]

Introduction and Objective: Mitochondrial dysfunction contributes to cardiovascular and microvascular disease risks in type 2 diabetes (T2D). This study investigates whether mitochondrial DNA copy number (mtDNA-CN) in whole blood can serve as a biomarker for these complications.Methods: mtDNA-CN was measured in the DNA extracted from whole blood samples of 497 T2D adults from the Fenofibrate […]