Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreMonth: May 2025
New Model of Experimental Diabetic Cardiomyopathy Using Combination of Multiple Doses of Anomer-Equilibrated Streptozotocin and High-Fat Diet: Sex Matters
Diabetes leads to a more rapid development of diabetic cardiomyopathy (dbCM) and progression to heart failure in women than in men. Combination of high-fat diet (HFD) and freshly injected streptozotocin (STZ) has been widely used for diabetes induction; however, emerging data show that anomer-equilibrated STZ produces an early-onset and robust diabetes model. We designed a […]
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Early increase in carotid intima-media thickness in women with childhood-onset type 1 diabetes compared with healthy peers: the Norwegian Atherosclerosis and Childhood Diabetes study
Research design and methods The Norwegian Atherosclerosis and Childhood Diabetes (ACD) study is a prospective population-based cohort study with follow-ups every fifth year. The cohort consists of subjects with childhood-onset T1D and a healthy control group with similar age and sex distribution. All examinations were conducted at Oslo University Hospital, Ullevål. Written informed consent was […]
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Vaping Doesn’t Help People Quit Smoking, Study Finds
Share on PinterestNew research found that people who vape and smoke cigarettes are less likely to quit than people who only smoke cigarettes. Lucy Lambriex/Getty Images Vaping does not help most people quit smoking cigarettes, according to a new study. People who vape and smoke cigarettes are far less likely to leave nicotine behind than […]
Read MoreDiabetes Core Update : Special Edition – Diabetes Core Update
In this special episode on Oral Health our host, Dr. Neil Skolnik will discuss practical approaches to helping patients achieve oral health which is of critical importance for people with diabetes. His guest for this episode is Dr. Wenche Borgnakke, and expert in public health and dentistry. This special episode is supported by an independent […]
Read MoreDeubiquitinating Enzyme USP2 Alleviates Muscle Atrophy by Stabilizing PPAR-γ
Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the role of ubiquitin specific peptidase 2 (USP2), a key regulator of insulin resistance, in sarcopenia remains unclear. Peroxisome proliferator–activated receptor γ (PPAR-γ) plays a critical role in regulating muscle atrophy. The role of deubiquitinase USP2 in mitigating muscle […]
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Incidence of metabolic and bariatric surgery among US adults with obesity by diabetes status: 2016–2020
Discussion From 2016 to 2020, over 900 000 MBS procedures were performed in inpatient and hospital-owned ambulatory surgical centers in the USA. For adults with or without diabetes, women and persons with class III obesity had a significantly higher incidence of MBS. Adults with obesity and diabetes had nearly threefold higher age- and sex-adjusted incidence of […]
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Exercise Lowers Death Risk by 60% in Cancer Survivors
Share on PinterestModerate daily exercise significantly reduced the risk of death from cardiovascular disease among female cancer survivors, a new study found SolStock/Getty Images Among older female cancer survivors, moderate daily exercise significantly reduced the risk of death from cardiovascular disease. Cancer survivors are statistically more likely to develop cardiovascular disease. Reducing sedentary time and […]
Read MoreDiabetes Core Update November 2024
Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreAtf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid
Glucolipotoxicity, caused by combined hyperglycemia and hyperlipidemia, results in β-cell failure and type 2 diabetes via cellular stress-related mechanisms. Activating transcription factor 4 (Atf4) is an essential effector of stress response. We show here that Atf4 expression in β-cells is minimally required for glucose homeostasis in juvenile and adolescent mice but it is needed for […]
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