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Reopening the Energy Deficit: Beige Adipocytes in Weight Loss Therapy
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Read MoreDiabetes Spotlight: John Ussher, PhD—Unlocking the Secret Cardiovascular Benefits of GLP-1–Based Medicines
“They say first impressions are important,” John Ussher says. He remembers giving a research presentation during his undergraduate years at the University of Alberta, his first time speaking publicly in front of a room full of professors. “There was no laser pointer,” he says. “I had a wooden stick, I was nervous, and I was […]
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Special Edition: What's Next—The Role of Health Systems in Managing CKD Associated with T1D & T2D
To achieve optimal outcomes for patients, it is not only the individual efforts of clinicians that matter in achieving optimal outcomes for our patients. Having a system that supports and facilitates those efforts is essential. In this special episode, Neil Skolnik speaks with Nihar Desai about the challenges of managing chronic kidney disease and diabetes. […]
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Impact of Finerenone on Albuminuria in T1D, National Trends in Out-of-Pocket Cost for Glucose-Lowering Drugs, and more!
Welcome to the latest episode (August 2026) of DOC Updates, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Updates: Hirsh Elhence, Jennifer L. Dodge, Stephen Fuest, et al. National Prevalence of Clinical Obesity by BMI Class: A National […]
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Special Edition: Hypertension Part I—Overview and Management
In the first episode of this special three-part series, Neil Skolnik speaks with Dr. Minesh Rajpal. Together, they provide an overview, discussing the assessment and management of high blood pressure. This special episode is sponsored with support from AstraZeneca. Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas […]
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Special Edition: Highlights from the ADA's 2026 Scientific Sessions
In this special crossover episode, recorded live at the American Diabetes Association’s Scientific Sessions in New Orleans, the hosts of the ADA’s professional podcasts—DOC Updates, Diabetes Care “On Air”, DiabetesBio, and The Points of CARE—come together to discuss key highlights and groundbreaking research presented at the 2026 meeting. They share expert insights across the bench-to-bedside […]
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Special Edition: Lp(a) & CV Risk
Over two decades ago, Lipoprotein(a)—or Lp(a)—was recognized as an emerging risk factor for cardiovascular disease. In this special edition of DOC Updates, Dr. Neil Skolnik explores our growing understanding of this cholesterol-carrying lipoprotein. This special episode is sponsored with support from Lilly. Please listen to the episodes by clicking on the podcast player below or […]
Read MoreMorning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action
The second-meal phenomenon refers to the improved glycemic response to a subsequent identical meal. We previously showed that morning hyperinsulinemia is a key mediator, priming the liver for enhanced net hepatic glucose uptake (NHGU) and glycogen storage during an afternoon hyperinsulinemic-hyperglycemic clamp. Postprandial NHGU is regulated by three primary mechanisms: insulin action, initiated by hyperinsulinemia; […]
Read MoreRBP4 Aggravates Diabetic Retinopathy by Inducing Microglial Activation and Endothelial Inflammation
Diabetic retinopathy (DR) is recognized as an inflammatory neurovascular complication, with neuronal deficits preceding vascular symptoms. This study identified elevated serum retinol-binding protein 4 (RBP4) as a risk factor for DR, because it induces retinal neuronal injuries and exacerbates vascular defects. Vitreous RBP4 levels were significantly elevated in patients with DR compared with those with […]
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