Category: Diabetes

Introduction and Objective: Guideline-directed medical therapy (GDMT) improves outcomes in people with type 2 diabetes (T2D) and chronic kidney disease (CKD) but remains underused, possibly due to low CKD screening rates. This study evaluated screening and GDMT prescribing patterns in people with T2D with and without CKD.Methods: We performed a retrospective analysis of active patients […]

Introduction and Objective: Gestational diabetes mellitus (GDM) affects ~12% of pregnancies and is associated with maternal and offspring perinatal complications and long-term metabolic risk. We assessed GDM-related knowledge gaps, perceptions, and support needs among women aged 20-49 years to inform seamless support across preconception, pregnancy, and postpartum periods.Methods: A nationwide cross-sectional web survey included women […]

Introduction and Objective: Circulating microRNAs (miRNAs) regulate metabolic and inflammatory pathways and may reflect genetic risk of type 2 diabetes (T2D) and renal failure (RF), captured through family history. Whether circulating microRNAs capture familial risk better than clinical characteristics is currently unknown.Methods: This cross-sectional design assessed a discovery subset (n=81) from a historical 2×2 factorial […]

Introduction and Objective: Most second-line antidiabetic agents are contraindicated during pregnancy; however, unintended exposure during early gestation is common. We assessed the risk of spontaneous abortion (SAB) associated with the continued use of second-line antidiabetics during early pregnancy.Methods: Using the National Health Information Database of Korea from 2012 to 2023, we identified pregnant women with […]

Introduction and Objective: Albuminuria incompletely predicts diabetic kidney disease (DKD) progression. Urinary post-translationally modified Fetuin-A (uPTM-FetA) reflects kidney stress-related pathophysiology. We evaluated whether uPTM-FetA predicts renal outcomes independent of albuminuria and eGFR in CREDENCE participants with type 2 diabetes and CKD.Methods: Baseline urine from 1,466 participants was analyzed for uPTM-FetA. Associations with UACR and eGFR […]

Introduction and Objective: Diabetic foot ulcers (DFUs) remain a major complication of diabetes associated with impaired healing and amputation risk. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment, but evidence continues to evolve. The objective of this updated systematic review and meta-analysis is to analyze the efficacy of hyperbaric oxygen for the […]

Introduction and Objective: Accurate risk stratification in Diabetic Kidney Disease (DKD) is often confounded by nephroprotective medications (e.g., SGLT2i) and the non-linear dynamics of traditional biomarkers in advanced stages. This study evaluated the disease specificity and independent prognostic value of a novel biomarker, uPTM-FetA/Ucr, across the diabetes disease continuum, in a real-world cohort.Methods: A cross-sectional […]

Introduction and Objective: Treatment discontinuation in painful diabetic peripheral neuropathy (PDPN) is common and may result in periods without active therapy. We used a decision tree model to evaluate how discontinuation patterns influence risk of diabetic foot ulcer (DFU), amputation, and costs.Methods: A decision tree simulated 1,000 adults initiating PDPN therapies modeling periods without treatment. […]

Introduction and Objective: Diabetes and chronic respiratory diseases (RD) frequently coexist and share inflammatory features. However, whether metabolic dysfunction similarly influences inflammatory and vascular profiles across these conditions is unclear.Methods: We investigated shared and disease-specific metabolic inflammatory patterns in diabetes, RD, and their coexistence. We analyzed 262 subjects after excluding major confounders. Participants were classified […]

Introduction and Objective: PA is often required for diabetes medications and technologies, but its impact on PwD is not well characterized. This study examined the perspectives of PwD regarding the PA process in diabetes care.Methods: A cross-sectional, anonymous survey was conducted among PwD aged ≥18 years or caregivers of children with diabetes in the U.S. […]