Category: Diabetes

Type 1 diabetes (T1D) is the most common chronic autoimmune disease in children, driven by a breakdown in self-tolerance and T cell–mediated immune attack of pancreatic β-cells. There are no biomarkers to effectively diagnose autoimmunity before disease onset and clinical symptom development. Here, we applied deep multiparametric immunophenotyping to compare immune landscapes in 38 patients […]

We read with great interest the recent article in Diabetes by Gonçalves et al. (1), reporting that functional pericyte coverage of islet capillaries is compromised at very early stages of β-cell loss and low-grade inflammation, before the onset of overt hyperglycemia. Using a subdiabetogenic streptozotocin mouse model, the authors demonstrated that altered pericyte-endothelial interactions were associated […]

Diabetes calls on thousands of scientific and medical experts each year to review manuscript submissions. The editors of Diabetes sincerely appreciate the efforts of all of our reviewers who volunteer their time and expertise to provide valuable feedback to ensure the consistently high quality of the research published in each issue. We would like to […]

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The high prevalence of enterovirus infections in the general population has made it difficult to consistently link these infections to type 1 diabetes or to identify specific associations with one or more serotypes. A temporal association between infections and diabetes onset, when known, is variable. Moreover, only a minority of those infected by enteroviruses develop […]

Through her parents, Dawn Davis was exposed to opposite ends of the medical field. Her mother worked and volunteered with community and health–related nonprofits. Her father was an engineer developing pacemakers and MRI machines. “I remember a prototype pacemaker at home, encased in liquid plastic,” Davis says, “and I was probably one of the first […]

We appreciate the thoughtful commentary from Zhu et al. (1) regarding our study on B lymphocytes and regulatory T cells (Tregs) in type 1 diabetes and islet transplantation (2). We are pleased that they highlight our central observations in the NOD background, including the ability of B-cell deficiency to permit anti-CD45RB–mediated tolerance in the autoimmune type […]

JDRF (Breakthrough T1D)3-PDF-2024-1503-A-NNIH RO1DK133483 and DK138471 Source link

We read with great interest the recent study by Wilson et al. (1), which demonstrated that B lymphocytes impair regulatory T cell (Treg) development and function, thereby eroding islet tolerance in the NOD islet allograft model. Their findings show that B-cell deficiency enables durable graft acceptance following short course anti-CD45RB treatment, accompanied by Helios+ Treg expansion, improved […]