In their recent article in Diabetes, Lin et al. (1) report an exceptionally strong correlation (r = −0.93) between insulin- and niacin-mediated suppression of FFA-palmitate Ra. Because these agents act through distinct proximal signaling pathways, this correlation, not only notable, is mechanistically constraining and directly informs the interpretation of adipose tissue (AT) dysfunction in obesity and […]
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CD8 + Memory T Cells Encode Obesogenic Memory in White Adipose Tissue
Obesity is associated with systemic energy imbalance and leads to a wide range of metabolic complications, including type 2 diabetes, fatty liver disease, and cardiovascular disorders. Therapeutic strategies for obesity, including lifestyle interventions such as exercise and dietary modification, bariatric surgery, and glucagon-like peptide 1 receptor agonists, have been widely implemented (1). However, rapid weight […]
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Special Edition: What's Next—Cortisol, Metabolism & Future Innovation, Part 4
Is hypercortisolism the hidden culprit in a significant proportion of both difficult-to-treat diabetes and resistant hypertension? In part 4 of our special series, Dr. Neil Skolnik speaks with John Buse, MD to explore the effects of hypercortisolism, until just recently considered a vanishingly rare condition. This special episode is sponsored with support from Corcept. Please […]
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Special Edition: What's Next—Cardiovascular Risk in CKD—The Overlooked Burden
We have only recently become aware of the close relationship between the heart and the kidneys. In today’s discussion, Dr. Neil Skolnik speaks with Dr. Josephine Harrington to gain insight into these newly-discovered links between cardiovascular risk and CKD. This special episode is sponsored with support from Bayer. Please listen to the episodes by clicking […]
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Special Edition: What's Next—Once-Weekly Insulin
In the early 2000s, long-acting, once-daily insulin was approved, completely changing the experience of using insulin for people with diabetes. But science doesn’t stand still. Now the FDA has approved weekly insulin. In this special episode of Diabetes Core Update, Neil Skolnik speaks with Athena Philis-Tsimikas, MD about this exciting development. This special edition of […]
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Associations between GLP-1 Receptor Agonists and Ischemic Optic Neuropathy, Tirzepetide vs. Dulaglutide or Semaglutide on major cardiovascular events in T2D, and more!
Welcome to the latest episode (May 2026) of Diabetes Core Update, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month, they discuss: Marston NA, Bohula EA, Bhatia AK, et al. “Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known […]
Read MoreBiallelic Pathogenic Variants in IL2RA Cause Neonatal-Onset Monogenic Autoimmune Diabetes
Autoimmune diabetes presenting in infancy or with additional autoimmune disorders can be the result of highly penetrant variants in key immune homeostasis genes. An example of this is observed with biallelic pathogenic variants in IL2RA (CD25), which causes immunodeficiency 41 (IMD41). IL2RA encodes the α-chain of the interleukin-2 receptor, which helps regulate the growth and […]
Read MoreEffects of Pancreatic Resection on Liver Fat Content and Amino Acid, Lipid, and Glucose Metabolism: A Prospective 1-Year Follow-up Study
Individuals who undergo pancreatic resection are at increased risk of developing hepatic steatosis. Glucagon is a key regulator of hepatic glucose, amino acids, and lipid metabolism, and the change in circulating glucagon is suggested to contribute to the pathogenesis of postoperative steatotic liver disease. Here, we aimed to elucidate hepatic and metabolic changes induced by […]
Read MoreANGPTL4 Induces Aberrant Lymphatic-Like Remodeling in Proliferative Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading cause of vision loss in working-age adults and often progresses to proliferative diabetic retinopathy (PDR) with irreversible complications. Anti–vascular endothelial growth factor (VEGF) therapy remains the first-line treatment; however, resistance poses a significant challenge, necessitating alternative therapeutic targets. This study explores the role of angiopoietin-like protein 4 (ANGPTL4) in […]
Read MoreNormalization of Insulin Resistance Rather Than Hyperglycemia Before Stroke Improves Functional Outcomes in a Mouse Model of Type 2 Diabetes
Prestroke hyperglycemia and insulin resistance (IR) independently correlate with poor stroke outcomes in type 2 diabetes (T2D), although their causative effect is undetermined. Interestingly, an increasing body of evidence points toward the importance of IR in determining stroke outcomes. Filling this gap is fundamental to identifying effective anti-T2D strategies to improve stroke prognosis in people […]
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