Category: Diabetes

Introduction and Objective: This study investigated the glucodynamics and hypoglycemia risk associated with exercise or fasting during once-weekly basal insulin icodec treatment.Methods: Thirty basal insulin-treated, physically active individuals with T2D were enrolled. Icodec was dosed for ≥7 wks to target FPG of 80-130 mg/dL. When icodec steady state was achieved, 40 min cycling (EXE; 60% […]

Introduction and Objective: FCL transcends reducing the burden of carbohydrate counting. FCL eliminates the need for meal management by the person with diabetes and restores the normal manner in which people without diabetes interact with food. That is a true freedom that people with diabetes have never known. A novel MiniMed™ FCL algorithm featuring personalized […]

Introduction and Objective: Pakistan has the highest diabetes prevalence globally, with more than 34.5 million affected individuals—a figure projected to reach 62 million by 2045. 1,2 Currently, 1 in 4 adults has diabetes. Over 24 million adults with diabetes are not receiving treatment, meaning 67% of diabetics in the country are untreated. 4Objectives:Awareness campaigns to […]

Introduction and Objective: There is a decades old perception that women of African descent prefer large body sizes. Even though body size preference is a major determinant of health behavior, the 21st century view of body size preference in African immigrant (Afr-Im) and African American (AA) women is unknown. Our goal was to assess and […]

Introduction and Objective: Pancreatogenic diabetes (T3cDM) results from pancreatic exocrine dysfunction leading to endocrine insufficiency. Although linked to acute/chronic pancreatitis (AP/CP) and pancreatic cancer (PC), the incidence and predictors of diabetes after these conditions require clarification. This study determines the pooled incidence of new-onset diabetes following AP, CP, and PC and identifies disease-specific risk factors.Methods: […]

Introduction and Objective: Multidisciplinary obesity and diabetes care requires coordination across providers and multiple data sources, often involving extensive time on documentation and chart review. We evaluated whether implementation of a real-time, AI-generated structured patient summary could improve clinician efficiency and satisfaction.Methods: In a large nationwide virtual obesity clinic, we conducted a pre-post evaluation of […]

Introduction and Objective: miRNAs are emerging as significant metabolic regulators and are altered at both the cellular and secreted levels in diseases, including type 2 diabetes (T2D). However, to what extent alterations in miRNA content and secretion are cell-intrinsic, and how they play a role in disease pathogenesis, remains unclear.Methods: In the present study, we […]

Introduction and Objective: Exocrine pancreas dysfunction is evident in presymptomatic type 1 diabetes (T1D), yet its natural history remains unclear. We evaluated whether longitudinal decline in fecal elastase (FE-1) tracks more closely with islet autoimmunity or progression to dysglycemia and assessed its predictive utility.Methods: In a nested case-control study within The Environmental Determinants of Diabetes […]

Introduction and Objective: Insulin resistance is a major risk factor in the development of type 2 diabetes (T2D) and metabolic syndrome. Although ~25% of people within the general non-diabetic population are insulin resistant, the primary underlying cause of insulin resistance remains elusive.Methods: In this study, we have used induced pluripotent stem cells (iPSC) derived from […]

Introduction and Objective: We are developing an ultra-stable insulin analog designed to address the intrinsic physical instability of current insulin formulations. Using advanced protein structural insights and protein engineering approaches originating from UT Southwestern, we focused on optimizing insulin analogs to reduce fibrillation and aggregation while improving resistance to thermal and mechanical stress across a […]