Category: Diabetes

Dietary, surgical, and pharmacological methods can effectively reduce body weight; however, rapid weight loss can also be accompanied by a loss of lean mass. Previously, we found that intestinal fibroblast growth factor 15 (FGF15; mouse ortholog of human FGF19) protects against lean mass loss after sleeve gastrectomy in mice and that circulating FGF19 predicts lean […]

The strongest type 2 diabetes signal in Indigenous Americans from Arizona is in intron 15 of KCNQ1. We previously identified a functional region in this intron that contained four type 2 diabetes–associated single nucleotide polymorphisms (SNPs) (rs2299620, rs2237896, rs2237897, and rs74046911) and demonstrated functionality of this fragment using Indigenous American induced pluripotent stem cell (iPSC)-derived […]

We previously identified six clusters of people at different risks of type 2 diabetes and/or comorbidities, of which cluster 3 (β-cell deficient) and 5 (older age, higher BMI, severe insulin resistance) had a high risk of progression to diabetes. We have now investigated whether cluster 3 and 5 individuals differed from those of the other […]

Refractory chronic diabetic wounds severely threaten patient survival; however, current treatments do not adequately promote healing. Cathepsin K (CTSK), a collagen-degrading protease upregulated in early diabetic wounds, presents a potential therapeutic target, and human umbilical cord mesenchymal stem cell–derived extracellular vesicles (hUMSC-EVs) show promise in regeneration but are associated with challenges related to production yield […]

In their comment letter in this issue of Diabetes, Ragozzino et al. (1) raise several points regarding our recent publication (2) that “warrant further clarification to strengthen the translational impact of the work.” They indicate that “several mechanistic interpretations . . . are inferred from indirect behavioral and metabolic proxies,” mainly that “meal size and meal […]

National Institutes of HealthR01EY023397R01EY029693American Diabetes Association10.13039/100000041Grant Ref #11-22-IBSPM-12 Source link

“It was always sports,” Jonathan Campbell says, describing his childhood. He grew up in Toronto, where his father worked as a hydrogeologist and his mother as a grade school teacher. His initial interest was soccer, but by high school his focus had shifted entirely to basketball. “I spent a lot of time on a basketball […]

American Neuromuscular Foundation10.13039/100025799Mid-career Research Grant Source link

National Institute of Diabetes and Digestive and Kidney Diseases10.13039/100000062R01-DK123259 Source link

The study by Shah and Ayala (1) offers a valuable temporal dissection of semaglutide’s effects on feeding behavior, energy expenditure (EE), and substrate oxidation in obese mice. By distinguishing rapid, gradual, and maintenance phases of weight loss and extending observations into the posttreatment period, the authors provide a timely framework for understanding the evolving physiology […]