TAS2R38 is a bitter taste receptor that influences bitter taste perception and diet and is also found in intestinal L cells that store and secrete glucagon-like peptide 1 (GLP-1). Preclinical studies have linked TAS2R38 activation to postprandial GLP-1 secretion, fueling interest in TAS2R38 as a therapeutic target for glucose regulation; however, evidence in humans remains […]
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Issues and Events
Issues and Events Source link
Read MoreThe Dark Proteome: “Not Everything That Counts Can Be Counted”
Juvenile Diabetes Research Foundation International10.13039/1000009012-SRA-2024-1550-S-B. Source link
Read MoreBeyond the Classical Axis: Metabolic “Pressure” on the Adrenal Gland?
Ministry of Research MURNext Generation EU PNRR PRIN project P2022EA9RR, Source link
Read MoreFrom Methylation to Metabolism: Linking Molecular Layers in Diabetes Risk
Type 2 diabetes risk has traditionally been assessed using fasting glucose, BMI, and lipid panels (1). Although these measures are easily accessible and scalable, they capture disease only after metabolic dysfunction has already been established, limiting the potential for prevention and hindering the effectiveness of interventions (2). This gap has motivated efforts to develop molecular […]
Read MoreDiabetes Spotlight: Sylvaine You, PhD—Preventing the Progression of Type 1 Diabetes Through Immunomodulatory Therapeutics
Science means constantly learning. “You have to constantly question yourself, because our understanding of the world changes all the time. We may have thought something 20 years ago which isn’t true anymore,” Sylvaine You says. “But it’s also very exciting, because you’re constantly discovering. New proteins, new molecules, new pathways, new mechanisms—it’s such a dynamic […]
Read MoreNUAK1 Promotes Diabetic Kidney Disease by Accelerating Renal Tubular Senescence via the ROS/P53 Axis
Diabetic kidney disease (DKD) progression involves intricate interactions among senescence, oxidative stress, inflammation, and fibrosis. This study systematically investigates the regulatory role and molecular mechanisms of NUAK1 in DKD pathogenesis. Bioinformatics analysis of Gene Expression Omnibus data sets identified NUAK1 as a differentially expressed gene, validated in human kidney proximal tubule epithelial (HK-2) cells, high-fat […]
Read MoreSpecial Edition – CVOTs Part 2
In this special series on The Cardiovascular Outcome Trials our host, Dr. Neil Skolnik will discuss the history and importance of the Cardiovascular Outcome Trials for diabetes medications. In Part 1 we discussed an historical perspective with Dr. Steven Nissen. Today we discuss with Dr. Darren McGuire the incredible evolution of the CVOTs since that […]
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Special Edition: What's Next—An Update on Beta Cell Function
In this special episode on a Beta Cell Update Dr. Neil Skolnik discusses this emerging area with Dr. Melena Bellin. This special episode is supported by an independent educational grant from Sanofi. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency […]
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Diabetes Core Update Nov 2025
This issue will review: 1. Effects of Semaglutide With or Without Concomitant Mineralocorticoid Receptor Antagonist Use in Participants With Type 2 Diabetes and Chronic Kidney Disease: A FLOW Trial Prespecified Secondary Analysis – Diabetes Care 2. Orforglipron, an Oral Small-Molecule GLP-1Receptor Agonist, in Early Type 2 Diabetes – NEJM 3. Orforglipron, an Oral Small-Molecule GLP-1 […]
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