Category: Diabetes

Introduction and Objective: Hypokalemia is associated with adverse cardiovascular outcomes in heart failure (HF) and may impair insulin release and action. However, whether hypokalemia promotes incident diabetes in HF is uncertain.Methods: In this FINEARTS-HF analysis, we evaluated the association between time-updated serum potassium levels and new-onset diabetes, defined as ≥2 HbA1c measurements ≥6.5% or initiation […]

Introduction and Objective: The rate of hypertensive disorders of pregnancy (HDP) is rising. HDP has been linked to pre-existing cardiometabolic (CM) risk factors, including insulin resistance (IR), BMI, blood lipids, and lactate. Therefore, we sought to understand if an association exists between these markers in early pregnancy and development of HDP in our population.Methods: This […]

Introduction and Objective: To investigate the associations between immune cell subset frequencies and metabolic features (including islet autoantibodies, fasting C-peptide [FCP], and HbA1c) in patients with type 1 diabetes (T1D) in China.Methods: This cross-sectional study enrolled 204 participants diagnosed with T1D. Flow cytometry was used to measure the immune cell subset (T/B/NK cells, Th cells, […]

Introduction and Objective: Despite the increased use of wearable technologies for self-management of type 1 diabetes, patients and families do not commonly download and review their data between clinic visits. The Diabetes, Data & Devices (D3) Education Program was developed to address this gap by providing structured education on diabetes data review and interpretation. This […]

Introduction and Objective: The benefits of diabetes self-management education and support (DSMES) are well-established. State Medicaid programs provide DSMES coverage. The objective was to obtain actionable data on utilization of DSMES among Medicaid enrollees with diabetes to inform strategies to increase use of services.Methods: This serial cross-sectional study analyzed Transformed Medicaid Statistical Information System (T-MSIS) […]

Introduction and Objective: Adolescents with type 1 diabetes (T1D) require contextually-aware, evidence-based self-management support. General-purpose large language models (LLMs) lack integration with systematically synthesized and appraised evidence or contextual tailoring. This study aimed to construct and evaluate T1DiaBot, a knowledge graph-grounded agent designed for adolescents with T1D.Methods: A self-developed “Evidence-to-Performance” (E2P) framework was followed: 1) […]

Introduction and Objective: Hypoglycemia causes an adrenergic response (AR) associated with epinephrine rise. We evaluated if change in heart rate (ΔHR), used as surrogate for AR, can distinguish between symptomatic and asymptomatic sensor-detected hypoglycemia (SDH), and factors affecting this, in type 2 diabetes. We focused on awake, symptomatic SDH<54mg/dL from people with intact awareness (Gold≤3), […]

Introduction and Objective: Accurate forecasting of continuous glucose monitoring (CGM) trajectories can support proactive diabetes management. We evaluated time-series foundation models (FMs) for CGM forecasting in two populations: type 1 diabetes and a combined non-diabetes/type 2 diabetes group. We assessed whether adding multimodal dietary context improves predictive performance.Methods: Using 8 CGM datasets, we compared FMs […]

Introduction and Objective: The overconsumption of fructose-rich western diets can cause metabolic dysfunction-associated kidney disease (MDAKD). We recently reported that high-risk Xor variants increase Xor and predispose to kidney disease in susceptible DBA/2J and B6Xorem1 vs. resistant C57BL/6J (B6) mice, with diabetes. However, the role of Xor risk variants in fructose-induced MDAKD has not been […]

Introduction and Objective: Novel once-weekly therapies targeting complementary pathways, such as basal insulin and GLP-1 RA, may simplify management and improve outcomes in type 2 diabetes (T2D). This study aimed to evaluate the short-term effects of icodec plus tirzepatide in a real-world setting.Methods: This retrospective observational study included 21 adults with long-standing T2D initiating icodec […]