Diabetic cardiomyopathy (DbCM) is a chronic metabolic disorder with few effective treatment strategies. Our previous study demonstrated that activated protein C (aPC), a serine protease, exerts cytoprotective effects in DbCM. However, the mechanisms underlying its role in DbCM require further elucidation. We developed a type 1 diabetic mouse model using thrombomodulin gene point mutation mice […]
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Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis
In mice, glucagon regulates lipid metabolism by activating receptors in the liver; however, its role in human lipid metabolism is incompletely understood. Here we describe three normal-weight individuals from a consanguineous family with early-onset hepatic steatosis and/or cirrhosis. Using exome sequencing, we found they were homozygous for two missense variants in the glucagon receptor gene […]
Read MoreDiabetes Spotlight: Rebecca Anne Haeusler, PhD—Investigating Metabolism Through Insulin Signaling
“I’m a scientist, and as a scientist, as you learn things, you realize there’s so much more that we don’t know. Answers just lead to more questions,” Rebecca Haeusler says. “We still have so much to learn about how the human body works.” Source link
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Read MorePredicting Sustained Benefit From Tirzepatide in SURPASS-4: Who Benefits and Why?
Bundesministerium für Bildung und Forschung10.13039/50110000234701GI0925 Source link
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When Is the Best Time to Get a Flu Shot?
Share on PinterestExperts say everyone who is eligible should get vaccinated against influenza this fall. Getty Images/Maskot Health officials anticipate this winter’s flu season to be moderate compared to last year’s severe season. Nonetheless, experts recommend that everyone who is eligible get vaccinated against influenza this fall. Experts say flu shots lower the risk of […]
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Younger Women May Face Overlooked Risk Factors
Share on PinterestMore than half of heart attacks in younger females could stem from causes other than artery blockage. Tashdique Mehtaj Ahmed/Getty Images Doctors often assume heart attacks in younger people arise from blocked arteries. However, a new study suggests that these heart attacks often have other causes. The researchers noted that this was especially […]
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Emotional Eaters Less Likely to Lose Weight on GLP-1 Drugs
Share on PinterestExperts say emotional eating should be addressed before a person is prescribed a weight loss drug. Justin Paget/Getty Images A new study reports that weight loss medications may not be as effective for people with emotional eating issues. Weight loss drugs work by suppressing hunger, so they may not be as beneficial for […]
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Weighted Vests Are Having a Moment, but Do They Live Up to the Hype?
Share on PinterestAre weighted vests really a fitness breakthrough? That depends on a lot of factors, including your current fitness level and goals. Yakov Knyazev/Stocksy United Weighted vests are trending, with proponents making many claims about the potential health benefits. Weighted vest training may help with cardiovascular fitness by increasing workout intensity. There is little […]
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Baseline and longitudinal changes of body roundness index and incident type 2 diabetes: evidence from the UK Biobank cohort
Discussion To the best of our knowledge, this is the initial large-scale cohort analysis in the UK to investigate the link between BRI and the development of T2D, incorporating the impact of longitudinal BRI changes. Our study identified significant associations between BRI and new-onset T2D. A J-shaped non-linear correlation of BRI and T2D risk was […]
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