Chronic overnutrition promotes excessive hepatic triglyceride accumulation, subsequently leading to insulin resistance and systemic metabolic dysfunction. Inorganic pyrophosphatase 1 (PPA1), an enzyme that hydrolyzes inorganic pyrophosphate, plays a key role in driving synthetic biochemical reactions. Here, we identified PPA1 as a novel regulator of systemic energy expenditure that functions by controlling hepatic production of fibroblast […]
Read MoreAuthor: sugaradmin
Integrating SMRT and Bulk RNA Sequencing With Metabolic Phenotyping to Examine Reduced Skeletal Muscle Mitochondrial Respiration in Type 2 Diabetes
Recent advances in RNA sequencing (RNA-seq) techniques allow the identification of tissue-specific alternative splicing and can thereby provide new insights into molecular mechanisms of energy metabolism. Full-length transcriptomics based on single-molecule real-time sequencing (SMRT-seq) enable precise detection of isoforms with 99% accuracy in an unbiased manner. In this proof-of-concept study, we integrated SMRT-seq, bulk RNA-seq, […]
Read MorePhase I Clinical Trial of Islet Antigen–Specific Plasmid Coexpressing Tolerogenic Proteins Demonstrates Safety in Adults With Type 1 Diabetes
There is significant interest in antigen-specific approaches to delaying type 1 diabetes in preclinical stages and supporting tolerance after diagnosis. We conducted a phase I trial of a nonintegrating DNA plasmid constructed to secrete the type 1 diabetes antigen preproinsulin (PPI) and the immune modulatory cytokines transforming growth factor-β1 (TGF-β1), interleukin-10 (IL-10), and IL-2. In […]
Read MoreDiabetes Spotlight: Martin Myers, MD, PhD—Understanding Metabolism and Glucose Through Neural Networks
“We moved a lot, but I did most of my growing up outside Iowa City, Iowa,” Martin Myers says. His father was a physician, but his family lived on a farm that grew corn and soybeans. They had horses. He and his brother raised sheep. “We got up to no good,” he says. “Banging around […]
Read MoreIssues and Events
Issues and Events Source link
Read More
Tirzepatide May Lower Risk of Diabetic Retinopathy
Share on PinterestTirzepatide may help lower the risk of diabetic retinopathy, a diabetes complication that can lead to vision loss. Douglas Sacha/Getty Images Weight loss medications Mounjaro and Zepbound, which contain the active ingredient tirzepatide, may lower the risk of diabetic retinopathy. This diabetes complication occurs when high blood sugar levels damage the blood vessels […]
Read More
Regular Exercise Could Help Minimize Complications
Share on PinterestResearch shows that increased physical activity may help prevent many diabetes complications. Image Credit: Alessandro Biascioli/Getty Images A recent study has found that many of the complications associated with diabetes, such as stroke and eye disease, are linked to low levels of physical activity. The researchers suggest that diabetes complications may be preventable […]
Read More
Sugary Drinks Linked to 34% Increase in Anxiety, Researchers Say
Share on PinterestA new study has linked sugar-sweetened beverages to anxiety symptoms in young people. Stockah/Getty Images Consumption of beverages high in sugar is associated with symptoms of anxiety in young people. High intake of sugary drinks is associated with a 34% increased risk of anxiety in adolescents. Experts say the spikes and crashes of […]
Read More
Exercise May Reduce Anxiety Symptoms, Boost Emotional Resilience
Share on PinterestA recent study suggests that higher fitness levels may help reduce anxiety and build resilience to stress. Image Credit: Oleg Breslavtsev/Getty Images Recent research has shown that people who have higher levels of physical activity may be more resilient during stressful situations. The research also found that physical activity may lead to lower […]
Read More
Moderate to Vigorous Exercise May Lower Cancer-Related Death Risk
Share on PinterestModerate to vigorous physical activity after a cancer diagnosis may help improve survival rates. Olga Pankova/Getty Images Researchers say engaging in regular physical activity may help improve cancer survival. They add that even people who were inactive prior to their diagnosis may benefit from exercise. Experts advise starting slow with a new exercise […]
Read More