Author: sugaradmin

Introduction and Objective: Obesity is a serious health issue for Indigenous Americans residing in Arizona and genetic factors are believed to play a role in the development of this chronic disease. The aim of this study was to identify and mechanistically study variants that associate with BMI. We identified 3 variants associated with BMI located […]

Introduction and Objective: Survodutide, a dual glucagon/GLP-1 receptor agonist in phase 3 trials for obesity and metabolic dysfunction-associated steatohepatitis, contains a C18-diacid half-life extension (HLE) group for once weekly dosing. This study thoroughly investigated the in vitro receptor pharmacology of survodutide and the impact of its HLE using time-resolved cellular assays.Methods: GCGR and GLP-1R both […]

Introduction and Objective: GDM dietary therapy targets maternal glycemia in gestation but fails to address postpartum metabolic disease risk. In an RCT, pregnant women on a higher-complex CHO diet showed an improved OGTT response at 36 wks’. We studied the diets’ sustained effect 2 mos postpartum (PP).Methods: At diagnosis, women with diet-managed GDM were randomized […]

Introduction and Objective: The hallmark of T1D is the destruction of pancreatic insulin producing β-cells by autoreactive T cells. The quest for new antigen-specific autoreactive cells as well as for strategies that may target them are highly required to provide a more successful therapeutic option for T1D. Starting from many evidence suggesting a potential role […]

Introduction and Objective: Metformin is an increasingly common medication used in pregnancy. However, metformin crosses the placenta raising concerns about unintended long-term effects to offspring health. This study examined whether metformin exposure during early development alters skeletal muscle metabolism in juvenile offspring and increases the risk of insulin resistance and obesity.Methods: Adult female Rhesus macaques […]

Introduction and Objective: Harmine (H) plus Exendin-4 (E) robustly enhances human β cell regeneration, yet whether H+E influences human β cell senescence is unknown. We developed a computational framework to resolve senescence heterogeneity in scRNA-seq and applied it to test whether H+E modulates senescence programs in cytokine-challenged vs. unchallenged human islets.Methods: We developed a machine-learning […]

Introduction and Objective: We assessed the efficacy of olezarsen, an antisense oligonucleotide targeting APOC3, in pts with severe hypertriglyceridemia (sHTG) and DM.Methods: The phase 3 RCTs CORE-TIMI 72a (N=617) and CORE2-TIMI 72b (N=446) randomized pts with sHTG (TG ≥500mg/dL) 1:1:1 to SC olezarsen 50mg, 80mg, or placebo Q4W for 12 mths. The primary endpoint was […]

Introduction and Objective: Polygenic scores (PS) are powerful predictors of type 1 diabetes (T1D) risk, but their performance can differ substantially across ancestries, highlighting the need for rigorous evaluation in different populations. In this study, we evaluated the performance of several established PS to predict T1D risk across ancestries in four biobanks: All of Us […]

Introduction and Objective: Triglyceride in low-density lipoprotein (TG-LDL) was considered a novel biomarker for coronary artery disease (CAD) from observational studies. We aimed to explore the causal relationship between TG-LDL levels and both overall and sex-specific CAD risk in individuals of European ancestry.Methods: We analyzed 487,759 European-ancestry participants from the UK Biobank and performed a […]