The unfolded protein response (UPR) drives events that promote diabetic retinopathy, including vascular endothelial growth factor (VEGF) upregulation in Müller cells. How UPR is activated in vivo in the diabetic retina is not well understood. CD40 is required for development of diabetic retinopathy, but whether CD40 mediates activation of UPR sensors is unknown. CD40 ligation in […]
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Diabetes in migrant communities: a rising healthcare priority
As of 2023, an estimated 281 million people globally are international migrants—constituting approximately 3.6% of the world population, reflecting steady growth over the past years.1 Non-communicable diseases, including diabetes, disproportionately impact migrant and ethnic minority populations due to a combination of genetic, environmental and socioeconomic factors.2 Previous studies in the USA and Europe have shown that […]
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Heavy Periods During Perimenopause Linked to Fatigue, Anemia
Share on PinterestHeavy menstrual bleeding is common during perimenopause and can lead to iron deficiency anemia, a well-known cause of fatigue. Maskot/Getty Images A recent study found that abnormal menstrual bleeding during perimenopause is associated with fatigue. If left untreated, heavy menstrual bleeding can lead to iron deficiency anemia, a well-known cause of fatigue. Females […]
Read MoreDiabetes Core Update January 2025
Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreDiroximel Fumarate Acts Through Nrf2 to Attenuate Methylglyoxal-Induced Nociception in Mice and Decrease ISR Activation in DRG Neurons
Diabetic neuropathic pain is associated with elevated plasma levels of methylglyoxal (MGO). MGO is a metabolite of glycolysis that causes pain hypersensitivity in mice by stimulating the phosphorylation of eukaryotic initiation factor 2α (p-eIF2α) and subsequently activating the integrated stress response (ISR). We first established that Zucker diabetic fatty rats have enhanced MGO signaling, engage […]
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Medication prescribing and pregnancy-related risk factors for women with type 2 diabetes of reproductive age within primary care: a cross-sectional investigation for the PREPARED study
Discussion This cross-sectional study indicates that women aged 18–45 years diagnosed with type 2 diabetes in South London are exposed to several factors that increase their pregnancy risk profile. With only 1 in 10 women in this cohort prescribed contraception by their GP, the risk of an unplanned pregnancy was high, even allowing for the […]
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Sale of Compounded Versions of Some Weight Loss Drugs to End
Share on PinterestPeople who rely on compounded GLP-1 drugs say they might not be able to afford brand-name versions, which are often not covered by insurance. Iuliia Burmistrova/Getty Images The FDA has ordered compounding pharmacies to stop making less expensive versions of popular weight loss medications like Ozempic and Zepbound. The order comes after federal […]
Read MoreDiabetes Core Update : Special Edition – Diabetes Core Update – CGM
Welcome to this special edition of Diabetes Core Update, where host Dr. Neil Skolnik takes a deep dive into the transformative role of continuous glucose monitoring (CGM) in diabetes care. Through engaging conversations with two leading experts, Dr. Skolnik explores the latest advancements in CGM technology, its clinical benefits, and its growing accessibility. Packed with […]
Read MoreMetabolic Dysfunction Associated With Alterations in Gut Microbiota in Adolescents With Obesity
Obesity in childhood is associated with adulthood obesity, type 2 diabetes (T2D), and future metabolic complications. The gut microbiota is a modifier of host metabolic function with altered bacterial composition associated with disease risk. Few studies have investigated the relationships among metabolic disease, inflammation, and the gut microbiota in youth, in whom these connections likely […]
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Resident memory CD8(+) T cells dominate lymphoid immune cell population in human pancreatic islets in health and type 2 diabetes
Results CD8(+) T cells, primarily with a central memory phenotype, are a major component of the lymphoid immune cell population in islets, with no significant differences between type 2 diabetic and non-diabetic donors. We initially analyzed the lymphoid composition of human pancreatic islets using multicolor flow cytometry on CD45(+) T cells from dispersed islets of […]
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