Author: sugaradmin

Introduction and Objective: To assess if glucagon-like peptide-1 receptor agonist (GLP-1 RA) compared with sodium-glucose cotransporter 2 inhibitors (SGLT-2i), is associated with an increased risk of motility-related gastrointestinal (GI) adverse events.Methods: From two US commercial healthcare databases, we used 1-1 propensity score matching on >150 potential confounders to identify a cohort of adults with type […]

Introduction and Objective: While the causes of lower-extremity amputation (LEA) are well-studied, the role of incident diabetic foot ulcer (DFU) has not been prospectively assessed. We evaluated the independent impact of DFU, alongside other factors, on LEA risk in a cohort of Veterans with diabetes at a single Department of Veterans Affairs clinic.Methods: A total […]

Introduction and Objective: The time of day that aerobic exercise is performed may alter the metabolic response leading to downstream effects on cardiometabolic health. This pilot study aimed to identify metabolites that are affected by time of day of exercise using metabolomics.Methods: Adults with overweight or obesity (BMI = 25-40 kg/m2) were randomly assigned to […]

Introduction and Objective: To identify risk factors and clinical outcomes for non-healing surgical wounds in patients admitted to the hospital for moderate and severe diabetic foot infections.Methods: This was a pooled analysis of patient level data from 2 RTCs. Moderate and severe diabetic foot infection (DFI) was based on criteria of the International Working Group […]

Introduction and Objective: Long-term impacts of gestational diabetes mellitus (GDM) on host metabolism are unknown. We aimed to identify serum metabolites linking history of GDM to type 2 diabetes (T2D).Methods: Among 2968 parous women in the Hispanic Community Health Study/Study of Latinos, we performed a metabolome-wide association analysis to identify metabolites associated with history of […]

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]

Introduction and Objective: Prediction of wound healing in DFU is clinically important to stratify risk of amputation and target limb salvage interventions. Basic and clinical studies show both initiation of ulcers and incomplete wound healing arising from reduced tissue perfusion and ischemia due to macro- and microvascular disease. Current vascular diagnostic modalities in clinical practice […]

Introduction and Objective: Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition where insulin resistance and impaired insulin secretion lead to hyperglycemia. Pancreatic β-cells regulate insulin production and secretion; however, pathological stressors encountered during diabetes development, including endoplasmic reticulum (ER) stress, contribute to decreased β-cell mass and function and altered cell identity. The ER […]

Introduction and Objective: Oxidative phosphorylation (OXPHOS) is a hallmark alteration in the diabetic kidney. However, it remains unclear whether this change occurs in kidney-resident macrophages (KRMs) and how this condition contributes to the progression of diabetic kidney disease (DKD).Methods: We investigated OXPHOS-related transcriptomic changes in KRMs within diabetic kidneys using single-cell RNA sequencing data derived […]