Uncontrolled and resistant hypertension is more common than we think. In the second episode of this special three-part series, Dr. Neil Skolnik discusses management strategies, but also explores our new understanding of aldosterone and its stealth role in hypertension. This series is supported with support from AstraZeneca. Please listen to the episodes by clicking on […]
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Selective advantages, selective mismatches, chronic inflammation, obesity, and type 2 diabetes: a new hypothesis to explain the effects of natural selection on genetic variation at the ectodysplasin A receptor locus
Development of ectodermal tissues in humans is a complex process regulated by interacting signaling pathways. This review adopts an evolutionary medicine framework to examine how genetic variation in components of the ectodysplasin A (EDA) signaling pathway may have conferred human evolutionary fitness during the last ice age, but today may present an evolutionary mismatch, contributing […]
Read MoreSubtypes of pre-diabetes in rural adolescent girls from India (DERVAN-11)
Introduction Pre-diabetes is becoming increasingly prevalent in adolescent populations. We recently reported a high prevalence of pre-diabetes among rural adolescent girls from the DERVAN cohort study established in the predominantly undernourished KONKAN region of India. We aimed to investigate the heterogeneity of pre-diabetes by identification of distinct subtypes. Research design and methods Anthropometry (body mass […]
Read MoreReproductive lifespan in relation to diabetes mellitus and metabolic syndrome in a nationally representative population
Aims The association between reproductive lifespan (RLS) and diabetes and metabolic syndrome in menopausal women remains unclear. We investigated whether a short RLS is associated with diabetes and metabolic syndrome using nationally representative US data. Methods We conducted a cross-sectional analysis of menopausal women using data from the US National Health and Nutrition Examination Survey […]
Read MoreFDA Approves 4 Updated Vaccines Targeting XFG Variant
Share on PinterestThe FDA has approved four updated COVID-19 vaccines that target the XFG variant. Luis Alvarez · DigitalVision/Getty The Food and Drug Administration (FDA) has approved four updated COVID-19 vaccines for the 2026–2027 season, all targeting the JN.1-lineage XFG variant. All four vaccines are approved for adults ages 65 and older, as well as […]
Read More1-Year Exercise Intervention May Help Reduce Recurrence
Share on PinterestA one-year clinical trial with a tailored exercise program reduced AFib recurrence by 45%. RealPeopleGroup/E+/Getty Images Exercise interventions are underutilized in the treatment of atrial fibrillation (AFib), an abnormal heart rhythm disorder. A one-year clinical trial with a tailored exercise program reduced time spent in atrial fibrillation by 45% compared with usual care […]
Read MoreCases Rising 3% Annually as Experts Urge Screening
Share on PinterestThe ACS notes that prostate cancer cases are on the rise, but early detection and screening may help reverse the trend. Maskot/Getty The American Cancer Society (ACS) estimates there will be 333,830 new cases of prostate cancer in 2026. Prostate cancer cases increased by around 3% per year between 2014 and 2022, with […]
Read MoreCan GLP-1 Drugs Like Zepbound Help With Symptoms?
Share on PinterestA new review found that GLP-1s offer significant improvements in obstructive sleep apnea associated with obesity. vitapix/E+/Getty Images New research has found that GLP-1 drugs may improve obstructive sleep apnea (OSA) related to obesity. The effects of tirzepatide (Zepound), which is FDA approved for OSA, were especially notable. GLP-1s appear to improve OSA […]
Read MoreRecombinant Vaccine May Lower Cardiovascular Disease Risk
Share on PinterestRecent research shows that the shingles vaccine may help reduce the risk of cardiovascular disease. A boy and the sea · E+/Getty A recent study found that the recombinant shingles vaccine (Shingrix) was associated with a 9% lower cardiovascular disease burden compared with the older live vaccine. Researchers observed lower burdens of coronary […]
Read MoreNew FDA-Approved Drug Doubles Survival Rates
Share on PinterestThe FDA approved Rasonque (daraxonrasib), a groundbreaking new drug to treat metastatic pancreatic cancer. Photo courtesy of Revolution Medicines The FDA approved Rasonque, a new drug to treat the most common type of pancreatic cancer. A clinical trial found that those who received Rasonque had more than double the average survival rate: around […]
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