Share on PinterestNew research found that consuming more ultra-processed foods is linked to an increased risk of multiple health conditions. LauriPatterson/E+/Getty Images A large study has found that eating more ultra-processed foods (UPFs) was linked to a higher risk of disease and early death. The risk of chronic diseases increased with higher UPF consumption, but […]
Read MoreIntroduction N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing for early heart failure (HF) detection in asymptomatic older adults with diabetes in the USA remains limited despite guideline recommendations. This study evaluated the cost-effectiveness of incorporating NT-proBNP testing into routine clinical assessments for adults aged ≥65 years from a Medicare perspective. Research design and methods A five-state […]
Read More
Share on PinterestGolden State Warriors v Phoenix Suns – Play-In TournamentPHOENIX, ARIZONA – APRIL 17: Stephen Curry of the Golden State Warriors during the first half of an NBA play-in tournament game at Mortgage Matchup Center on April 17, 2026 in Phoenix, Arizona. (Photo by Christian Petersen/Getty Images) NBA All-Star Stephen Curry is opening up […]
Read MoreThe progressive decline in functional β-cell mass represents a fundamental, unmet challenge in type 2 diabetes (T2DM) management. Dorzagliatin (HMS5552), a fourth-generation, dual-acting, and glucose-dependent glucokinase activator (GKA), offers a distinct mechanistic approach that aims to move beyond symptomatic glycemic control toward potential glucose sensor modulation. This review critically synthesizes the development of dorzagliatin, designed […]
Read More
Share on Pinterestnew research suggests that macromastia is associated with more than just physical pain and discomfort. Luis Alvarez/DigitalVision/Getty Images A new study found that women with macromastia (enlarged breasts) had higher odds of chronic migraine, neck pain, and obstructive sleep apnea than women without the condition. The findings suggest that macromastia may lead to […]
Read More
Welcome to the latest episode (October 2026) of DOC Updates, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease. This month on DOC Updates: Zoungas et al; Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults. New England Journal of Medicine, 28 August […]
Read MoreObjective To assess the association between Life’s Essential 8 (LE8) cardiovascular health score and prevalent microvascular complications in Chinese adults with type 2 diabetes mellitus (T2DM) and to explore whether this association differed by sex and menopausal status. Research design and methods We conducted a cross-sectional analysis of 4527 adults with T2DM in the Metabolic […]
Read More
Share on PinterestThe Eli Lilly headquarters in Indianapolis, IN, on August 15, 2024. AJ Mast/Bloomberg via Getty Images The FDA approved a new oral combo drug for a common breast cancer mutation on September 18. The treatment includes Inluriyo (imlunestrant) taken with Verzenio (abemaciclib) for adults with ER-positive, HER2-negative advanced or metastatic breast cancer with […]
Read Moreβ-Cell maladaptive unfolded protein response is a shared pathogenic feature of type 1 and type 2 diabetes, yet therapeutic strategies that selectively restore β-cell proteostasis remain limited. Zinc transporter 8 (ZnT8) is an islet-restricted endoplasmic reticulum (ER)–resident membrane protein whose folding burden is amplified under inflammatory stress. Here, we show that cell surface–directed ZnT8 antibodies […]
Read MoreGlucose-dependent insulinotropic polypeptide (GIP) promotes nutrient storage, but its vascular actions in skeletal muscle remain unclear. To determine whether GIP regulates muscle microvascular perfusion, a key determinant of substrate use, we examined GIP receptor (GIPR) expression in vascular endothelium and assessed GIP effects in vivo in chow-fed and high-fat diet (HFD)–fed rats. Overnight-fasted rats received 120-min […]
Read More