Month: September 2025

Following the trends of the adult obesity epidemic, and worsened by school disruptions during the coronavirus disease 2019 pandemic, childhood obesity prevalence has reached unprecedented levels. The health implications for this generation are especially concerning, as childhood-onset obesity has more severe health consequences than weight gain that begins in adulthood, including increased risk of type […]

Diabetes triggers cell-type-specific responses in the retina, leading to vascular lesions, glial dysfunction, and neurodegeneration, all of which contribute to the progression of diabetic retinopathy (DR). However, the specific cell types involved in disease development and the molecular mechanisms driving their responses have not yet been fully clarified, impeding the creation of effective therapeutic strategies. […]

This study aimed to investigate the relationship between the plasma lipidome and metabolic dysfunction–associated steatotic liver disease (MASLD) in type 2 diabetes. Initially, we conducted a plasma lipidome analysis using supercritical fluid chromatography–tandem mass spectrometry in 143 patients with type 2 diabetes with and without MASLD. Of the 349 lipid species identified, 13 had higher […]

Diabetic cardiomyopathy (DbCM) is a chronic metabolic disorder with few effective treatment strategies. Our previous study demonstrated that activated protein C (aPC), a serine protease, exerts cytoprotective effects in DbCM. However, the mechanisms underlying its role in DbCM require further elucidation. We developed a type 1 diabetic mouse model using thrombomodulin gene point mutation mice […]

In mice, glucagon regulates lipid metabolism by activating receptors in the liver; however, its role in human lipid metabolism is incompletely understood. Here we describe three normal-weight individuals from a consanguineous family with early-onset hepatic steatosis and/or cirrhosis. Using exome sequencing, we found they were homozygous for two missense variants in the glucagon receptor gene […]

“I’m a scientist, and as a scientist, as you learn things, you realize there’s so much more that we don’t know. Answers just lead to more questions,” Rebecca Haeusler says. “We still have so much to learn about how the human body works.” Source link

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Bundesministerium für Bildung und Forschung10.13039/50110000234701GI0925 Source link