Type 1 diabetes results from the immune-mediated loss of insulin-producing pancreatic islet β-cells, rendering those affected dependent on exogenous insulin to survive. Despite the array of choices available for insulin delivery, treatment to maintain near-normal glucose metabolism while avoiding hypo- and hyperglycemia remains a challenge. After two decades of clinical trials across four continents, the […]
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The Dorsal Raphe Nucleus and the Integrative Control of Feeding: A Report on Research Supported by Pathway to Stop Diabetes
Obesity is a major risk factor for the development of type 2 diabetes (T2D). While the connection between these two disease entities is still incompletely understood, even modest weight loss can greatly reduce the risk of developing T2D and its sequelae. With the recent success of antiobesity pharmacotherapies, which appear to exert their effects largely […]
Read MoreEmpagliflozin Enhances Hepatic Glucose Production and Reduces Total-Body Norepinephrine Turnover Rate: A Randomized Trial
The current study examined the effect of empagliflozin on hepatic glucose production (HGP) and total-body norepinephrine (NE) turnover in individuals with and without type 2 diabetes (T2D). The study randomized 36 individuals with T2D and 36 individuals without T2D to receive in a double-blind fashion empagliflozin or matching placebo (2:1 ratio) for 12 weeks. HGP […]
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Read MoreDiabetes Spotlight: David J. Hodson, BVSc, PhD, FRCVS—Regulation of Insulin and Glucagon in Pancreatic Islet Biology
In the Pennines, a range of moorland hills in northern England, it rains for much of the year. “The grass grows very green, very long, and as a consequence, the cows produce a lot of milk,” David Hodson says. As a kid growing up in this farmland outside of Manchester, Hodson always saw the livestock […]
Read MoreDNA Methylation Biomarkers Predict Offspring Metabolic Risk From Mothers With Hyperglycemia in Pregnancy
Gestational diabetes mellitus affects almost 18 million pregnancies worldwide, increasing by >70% in the past 20 years. DNA methylation has been associated with maternal hyperglycemia and type 2 diabetes risk in offspring. This study hypothesized that hyperglycemia during pregnancy influences DNA methylation changes at birth that mediate metabolic risk in offspring. Cord blood samples (n […]
Read MoreTargeting Adipose Inflammation and Energy Expenditure to Sustain Metabolic Health After Weight Loss
Deutsches Zentrum för Diabetesforschung10.13039/100031584 Source link
Read MoreIslet Autoantibody Testing as Type 1 Diabetes Early Detection Enters Mainstream Health Care
Diabetes UK10.13039/50110000036119/000610822/0006452Breakthrough T1D3-SRA-2024-1583-S-B3-SRA-2024-1584-S-BThe Leona M. & Harry B. Helmsley Charitable TrustG-2203-05808RFP-S-701991-5021-001 Source link
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Study Finds Sharp Increase In Access to Oral Contraceptives
Share on PinterestA new study found that OTC birth control has significantly expanded access to a safe and reliable birth control method. Carol Yepes/Getty Images In 2023, the FDA approved Opill, the first over-the-counter oral contraceptive that became widely available at in-person and online pharmacies. Researchers examined whether Opill increased birth control access and found […]
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Weekend Habits Linked to New Sleep Disorder
Share on PinterestObstructive sleep apnea symptoms may worsen on weekends, a trend researchers are calling “social apnea.” Getty Images A large study found that moderate to severe obstructive sleep apnea symptoms are more likely to occur on weekends, a trend researchers are calling “social apnea.” Late nights, sleeping in, alcohol, and skipping CPAP therapy could […]
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