Month: July 2025

Introduction and Objective: Although achieving a healthy weight prior to pregnancy is recommended, data on the association between preconception weight changes and pregnancy outcomes are limited. We examined the relationship between preconception weight trajectories and risk of GDM in a large, diverse cohort.Methods: We conducted a retrospective cohort study of 257,017 pregnancies resulting in singleton, […]

Introduction and Objective: Semaglutide once-weekly(SOW)/Ozempic is used for the management of T2DM and/or obesity (off-label) in Canada. There was a supply shortage of SOW during Oct 2023- Jan 2024. We aimed to explore the glycemic impact, management changes and sentiments related to the shortage.Methods: A phone survey of 159 consenting adults prescribed SOW for T2DM […]

Introduction and Objective: Prediabetes (PreD) and type 2 diabetes (T2D) are increasingly common in young adulthood, a period of declining physical activity (PA). We investigated associations between individual- and community-level social determinants of health (SDOH) and PA in young adults with and without PreD or T2D.Methods: We conducted a cross-sectional study using survey and Fitbit […]

Introduction and Objective: Testing HbA1c in undiagnosed asymptomatic thalassemia traits/carriers in prevalent regions can be problematic because HbA1c values may falsely be altered, potentially leading to inappropriate management.Methods: This cross-sectional study evaluated 397 individuals who underwent annual health screening and thalassemia genetic testing in a tertiary care hospital. Of this cohort, 85 iron-deficient and 16 […]

Introduction and Objective: We examined medication adherence as a predictor of glycemic outcomes and evaluated treatment group differences in the GRADE study.Methods: GRADE participants (T2DM <10 years, HbA1c = 6.8-8.5%, on metformin monotherapy) were randomly assigned to add insulin glargine, glimepiride, liraglutide, or sitagliptin. The Emotional Distress Substudy followed 1,739 participants who self-reported adherence to […]

Introduction and Objective: The prevalence of PD and T2D has been steadily increasing. Thus, early risk markers for PD and T2D in individuals with NG are critically important. We asked whether Insulin Resistance Risk Score (IRRS) could be an early risk marker for future PD or T2D.Methods: Individuals with NG (FPG <100 mg/dL and HbA1c […]

Introduction and Objective: The global prevalence of type 2 diabetes mellitus (T2DM) is widely recognized to be on the rise. It is of great significance to reveal the current status of antidiabetic therapy in patients with T2DM.Methods: “Real-world Multicenter Registry to Determine Management and Quality of Care of Patients With Type 2 Diabetes in China” […]

Introduction and Objective: Hyperglycaemia has emerged as a significant complication in COVID-19, particularly in India, where the prevalence of diabetes is high. The objective of this study was to determine the prevalence, clinical manifestations, severity, and outcomes of new-onset hyperglycaemia in COVID-19 patients without pre-existing diabetes.Methods: A retrospective observational study was conducted on 2750 hospitalised […]

Introduction and Objective: Incretin drugs effectively promote weight loss, but also cause inevitable lean mass loss, compromising weight loss quality (WLQ). Urocortin-2 (UCN2) shows potential for enhancing lipolysis and muscle hypertrophy, offering a strategy to improve WLQ. To achieve these outcomes, a novel corticotropin-releasing factor receptor-2 (CRFR2) selective UCN2 analog, HM17321, was developed. The present […]

Introduction and Objective: This study aimed to evaluate the feasibility of a community-supported initiative for diabetes screening and management in a rural community in Bangladesh.Methods: Our community-supported initiative comprised design ethnography to understand the community and identify local resources. Then, community organization was facilitated by forming a health and inclusion committee after obtaining approval from […]