Month: June 2025

Islet cell replacement therapies have evolved as a viable treatment option for type 1 diabetes complicated by problematic hypoglycemia and glycemic lability. Refinements of islet manufacturing, islet transplantation procedures, peritransplant recipient management, and immunosuppressive protocols allowed most recipients to achieve favorable outcomes. Subsequent phase 3 trials of transplantation of deceased donor islets documented the effectiveness […]

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in individuals with diabetes. Individuals with type 1 diabetes have a two- to fourfold higher risk of CVD in comparison with the general population, driven by an earlier onset and increased lifetime incidence of CVD events and mortality. Similarly, type 2 diabetes confers two- […]

This year marks the 75th anniversary of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health. NIDDK’s long history of research and innovation includes support of four types of collaborative research centers focused on diabetes, endocrinology, and metabolic diseases. The Diabetes Research Centers promote basic and clinical […]

In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this research has been the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), most recently through the Accelerating Medicines Partnership Program for Type 2 Diabetes (AMP T2D) and Accelerating Medicines […]

National Research Foundation of Korea (NRF)NRF-2020R1A3B2078617RS-2023-00218616RS-2024-00460865 Source link

The study by Kohda et al. (1) in this issue of Diabetes is a remarkable contribution to the field of adipose tissue biology and metabolic research. The authors have used cutting-edge single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to dissect the intricate cellular interactions within adipose tissue during obesity-induced fibrosis. Their identification of novel cell-to-cell communications […]

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Growing up, Carmella Evans-Molina felt there were limited options for a girl in West Virginia coal country. She grew up in the shadow of Kopperston Mountain, living, until age 4, in a row house in an old coal camp—“rows and rows of houses that all looked the same,” she says—the vestige of a company town. […]