Month: May 2025

Glucagon stimulates hepatic glucose production, in part by promoting the uptake and catabolism of amino acids. Inhibition of the liver glucagon receptor (GCGR) results in elevated plasma amino acids, which triggers the proliferation of pancreatic α-cells, forming a liver–α-cell loop. This study aims to delineate hepatic signaling molecules downstream of GCGR that mediate the liver–α-cell […]

Effective treatment strategies for diabetes-related pain are limited because of its complex pathogenesis, particularly brain mechanisms underlying this disease. The acid-sensing ion channel 1a (ASIC1a) has emerged as a key player in the development and treatment of various types of pain. We investigated the role of ASIC1a in diabetes-related pain and its molecular mechanisms in […]

How immune tolerance to pancreatic islets is lost in type 1 diabetes (T1D) is a central question in the field. Clues come from the cancer field, where CD4 and CD8 T-cell responses are detected to posttranslationally spliced proteins that form hybrid neoepitopes (1,2). The discovery of hybrid insulin peptides (HIPs) in pancreatic islets offers a […]

Bonami and colleagues (1) demonstrate an obligatory role of BCL6-driven T follicular helper (Tfh) cells in the pathogenesis of type 1 diabetes (T1D). Their findings reveal that Bcl6 deficiency in T cells protects against diabetes, thus highlighting BCL6 as a promising therapeutic target to ameliorate T1D. Source link

Why did diabetes cases in South Korea surge in the 1990s and early 2000s? “We’re not sure. It probably aligned with rapid economic growth and drastic lifestyle changes,” Soo Heon Kwak says. “More automobiles, high-energy food intake, less exercise.” He was attending Seoul National University College of Medicine at the time, and when choosing a […]

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National Health and Medical Research Council10.13039/501100000925App2025795 Source link

In this special episode on Obstructive Sleep Apnea our host, Dr. Neil Skolnik will discuss an overview of OSA. In Part 2 we will take a deep dive into diagnosis, Part 3 will discuss treatment options, and Part 4 will look at cases. This special episode is supported by an independent educational grant from Lilly. […]