Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreMonth: May 2025
Comparison of the Effects of SGLT-2i Versus GLP-1RA on Cardiovascular and Renal Outcomes in Patients With Type 2 Diabetes, Based on Baseline Renal Function
Finding no head-to-head research evaluating the cardiovascular and renal benefits of sodium–glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) in patients with type 2 diabetes (T2D) at different baseline renal function, we performed a network meta-analysis to compare the two drugs indirectly. Systematic literature searches were conducted of the PubMed, Cochrane […]
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Role of 2-hour plasma glucose in assessing pre-diabetes risk: insights from the vitamin D and type 2 diabetes (D2d) study cohort
Historically, an elevated level of 2-hour plasma glucose (2hPG) during a 75-gram oral glucose tolerance test (OGTT) was the hallmark of pre-diabetes. This measurement served as a primary criterion in pivotal diabetes prevention clinical trials, including the Diabetes Prevention Program.1 However, with the American Diabetes Association (ADA) expanding its diagnostic criteria for pre-diabetes in 2010 […]
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Arnold Schwarzenegger Shares Tips on Preserving Joint Health, Mobility
Share on PinterestArnold Schwarzenegger wants those with joint pain and mobility issues to know they are not alone. Klaus Pressberger/SEPA.Media /Getty Images Revered actor and former politician Arnold Schwarzenegger shares his passion for physical activity. Schwarzenegger is spreading awareness about how regular movement can help with mobility issues. The “Terminator” legend recently launched the You’ll […]
Read MoreDiabetes Core Update : Special Edition
Welcome to the first episode in a special three-part series of the Diabetes Core Update podcast, focused on heart screening in people with diabetes. Sponsored by Roche, this series explores “heart failure with preserved ejection fraction” (HFpEF), providing primary care clinicians and healthcare professionals with essential insights into screening, diagnosis, and management of this increasingly […]
Read MoreDifferential Effects of Retinol-Binding Protein 3 and Anti-VEGF Antibodies on Retinal Dysfunctions in Diabetic Retinopathy
Anti–vascular endothelial growth factor (anti-VEGF) therapies are effective treatment for severe diabetic retinopathy (DR) and macular edema, but a significant subset of people had inadequate response to anti-VEGF intervention. Because elevation or overexpression of retinol binding protein 3 (RBP3) decreases risks for retinal pathologies and progression to severe DR, we compared the therapeutic profiles of […]
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Clinical phenotyping of people living with type 1 diabetes according to their levels of diabetes-related distress: results from the SFDT1 cohort
Results We analyzed data from 1220 adults with type 1 diabetes in France, covering 39 diabetic centers (online supplemental figure S3). The mean age was 42.0 (SD 13.9) years, with average diabetes duration at 24.7 (13.6) years, and 617 (50.6%) were females. Among SFDT1 respondents, 775 (63.5%) used insulin pumps, of which 150 (19.4%) used […]
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What to Know About the Drug
Share on PinterestIn Season 3 of “The White Lotus,” some characters pop lorazepam like candy, highlighting the potential for dependency and misuse. CHANAKARN LAOSARAKHAM/AFP via Getty Images Lorazepam, a common anti-anxiety medication, makes frequent appearances in Season 3 of “The White Lotus” on HBO. This type of benzodiazepine used to treat anxiety, panic attacks, and […]
Read MoreRespiratory Vaccinations and Combating Vaccine Hesitancy in People With Diabetes–December 2024
In this special episode of Diabetes Core Update, our host, Dr. Neil Skolnik, discusses with two expert guests the recommendations for respiratory vaccinations in people with diabetes, the rise in vaccine hesitancy and some of the possible reasons for this hesitancy, and several ways to address vaccine hesitancy in the office. This special edition is sponsored […]
Read MorePadi4-Dependent NETosis Enables Diet-Induced Gut Hyperpermeability, Translating Dysbiosis Into Systemic Inflammation and Dysmetabolism
Microbial signals trigger the release of neutrophil extracellular traps (NETs) through peptidyl arginine deiminase 4 (PADI4). In turn, NETosis can propagate inflammation to distant tissues. We hypothesize that PADI4 mediates the interactions between diet-modified microbiota and host metabolism. We report that in the adipose tissue of individuals with obesity, NETosis was associated with dysglycemia. In […]
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