Category: Diabetes

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Bundesministerium für Bildung und Forschung10.13039/50110000234701GI0925 Source link

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]

In this special episode on Strategies for Staying Full and Satisfied, our host, Dr. Neil Skolnik will moderate a discussion with Lily Correa, registered dietitian about communicating strategies for staying full and satisfied. This special edition of Diabetes Core Update is sponsored by Avocados – Love One Today ®.    For more information, as well as […]

This study compares novel type 1 diabetes–related autoantibody assays developed to improve upon the standard radiobinding assay (RBA). Samples from 1,505 individuals, followed for 5 years or to clinical type 1 diabetes, originally tested by RBA were aliquoted and sent blindly to five laboratories (Barbara Davis Diabetes Center [BDC], Institute of Diabetes Research [IDR], Diabetes […]

Obesity-induced biologic changes often persist after weight loss and are difficult to reverse, a phenomenon known as obesogenic memory. This enduring effect is associated with metabolic inflammation, particularly in adipose tissue. In this study, we characterized a mouse model of obesogenic memory and evaluated the efficacy of the unimolecular conjugate glucagon-like peptide 1 (GLP-1)/dexamethasone (GLP-1/Dexa), […]

Type 1 diabetes (T1D) results from a complex dialogue between the immune system and islets characterized by T cell–mediated autoimmune destruction of pancreatic β-cells. In this dialogue, β-cell stress responses have emerged as drug targets for slowing T1D progression, including a subpopulation of senescent β-cells that accumulate during T1D in humans and nonobese diabetic (NOD) […]

Evidence of retinal vascular inflammation accompanies diabetic retinopathy (DR) progression, and inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β) are experimentally linked to several hallmark DR features, including retinal leukostasis. Cannabinoid receptor 2 (CB2) agonism has been shown to decrease inflammatory cytokine production and leukocyte recruitment and adhesion in nonocular inflammation models, suggesting CB2 […]

Impaired cardiac ketone oxidative capacity is a possible disease mechanism in the development of diabetic cardiomyopathy. We examined whether the cardiovascular effects of ketone bodies are different in patients with type 1 diabetes (T1D) compared with healthy control individuals. In a single-blind study with a crossover design, nine patients with T1D and eight age-matched, healthy […]

By augmenting ATP-sensitive K+ channel–induced membrane depolarization, chronic metabolic stress in prediabetes may increase intracellular Ca2+ concentrations in pancreatic β-cells and cause a loss of cell identity and function. Here, we describe studies of the temporal transcriptomic dynamics induced by sulfonylurea-induced membrane depolarization. Gene expression in isolated islets is highly dynamic, with changes occurring within […]