Category: Diabetes

Introduction and Objective: DA-1241, a novel G protein-coupled receptor 119 agonist, recently completed a Phase 2a clinical trial in presumed metabolic dysfunction-associated steatohepatitis (MASH) patients. This study extended previous findings on its hepatoprotective synergy with glucagon-like peptide-1-based drugs and evaluated its anti-MASH effects in combination with a fibroblast growth factor 21 analogue.Methods: Male C57BL/6JRj mice […]

Introduction and Objective: Dementia, an emerging complication of type 2 diabetes (T2D), may be driven by chronic hyperglycemia and insulin resistance. We evaluated the risk of dementia across T2D subtypes, which differ in clinical profiles and risk of vascular complications.Methods: We identified newly diagnosed T2D (n = 727,076; age: 64.4 years [SD:13.3], 52% female) over […]

Introduction and Objective: An increasing number of individuals with normal weight are attempting weight loss through caloric restriction. However, most weight loss attempts are followed by weight regain, leading to weight cycling. Whether weight cycling poses metabolic risks, especially in normal-weight individuals, remains debated. This study aims to evaluate the effects of weight cycling on […]

Introduction and Objective: Characterize breadth of benefits, relationships among changes, and processes of change in Community-Based Peer Support (CPS).Methods: CPS was implemented over 24 months in 12 communities (n=1,018) with 4 Comparison Communities (Comp, n=423) in Shanghai, China. CPS participants were = 59.9% female vs 53.5% among Comp, older (mean 66.64 vs 62.94 years), and […]

Introduction and Objective: The present study aimed to investigate the hepatoprotective effects of OPK-88006, a novel GLP-1/glucagon receptor agonist, in the GAN diet-induced obese and biopsy-confirmed mouse model of MASH with liver fibrosis. The late-stage clinical candidates semaglutide and survodutide for the treatment of patients with MASH and liver fibrosis, were included for comparison.Methods: Male […]

Introduction and Objective: Islet endocrine cells rely on efficient prohormone synthesis and elimination of misfolded peptides for proper function. We recently found that endoplasmic reticulum-associated degradation (ERAD) and autophagy are essential protein quality control systems that maintain α cell identity, ER homeostasis, and glucagon (Gcg) production.Methods: To investigate whether ERAD and autophagy serve overlapping roles […]

Introduction and Objective: Metabolic dysfunction-associated steatohepatitis (MASH), a critical stage in NAFLD progression, lacks effective treatments. While GIP/GLP-1R dual agonists (GIP/GLP-1RA) show therapeutic potential, their mechanisms remain unclear. Our preclinical study identified serum BHMT downregulation by GIP/GLP-1RA. This study investigates the BHMT-incretin relationship, its roles in MASH pathogenesis, and its potential as a therapeutic target […]

Introduction and Objective: Understanding the relationship between diabetes, sarcopenia, and lifestyle factors like diet and physical activity remains limited, particularly in the MENA region. While most research focuses on individual nutrients, a dietary pattern approach offers a more comprehensive perspective. This study examines the impact of dietary patterns and diabetes on sarcopenia risk among adults […]

Introduction and Objective: T2D evolves through progressive loss of β-cell secretory capacity and insulin reserve. Non-invasive detection of insulin depletion in β-cells has not been possible. We tested a flux-based method for identifying reduced β-cell insulin stores non-invasively. The time for newly synthesized Ins and C-P to appear and become fully labeled in plasma reveals […]

Introduction and Objective: Automated insulin delivery (AID) is expected to reduce the burden of hypoglycemia including fear of hypoglycemia (FOH) in type 1 diabetes (T1D). This study aimed to evaluate the change in hypoglycemia fear survey-II (HFS-II) scores and hypoglycemia frequency after AID initiation in usual-living conditions.Methods: Adults (≥18years) living with T1D from the Canadian […]