Category: Diabetes

Introduction and Objective: Obesity presents a major global health concern with increasing prevalence worldwide. Currently, GLP-1 based therapies present the most effective treatment for obesity, but their tolerability and efficacy are limited by gastrointestinal side effects and compensatory reduction in energy expenditure (EE). Mitochondrial uncoupling by protonophores was shown to increase EE and reduce body […]

Introduction and Objective: MODY is frequently misdiagnosed, but accurate diagnosis can afford alternate management options. Prevalent barriers to MODY identification include lack of familiarity with MODY testing guidelines and insurance denial for testing. We launched a quality improvement (QI) project in 2022 at a pediatric, tertiary care center which aimed to: (1) increase the number […]

Introduction and Objective: Impaired adipocyte differentiation contributes to insulin resistance and obesity-related type 2 diabetes. Mitochondrial dysfunction is central to impaired adipogenesis. This study investigates how nuclear-encoded circRNA circBirc6 regulates mitochondrial function and adipogenesis, and its role in metabolic disorders.Methods: We used obesity and adipose-specific circBirc6 knockdown mouse models, and clinical samples from obese and […]

Introduction and Objective: T2D presents significant challenges to health outcomes, necessitating effective strategies to optimize glycemic levels. This study examines the impact of tech empowered personalized lifestyle coaching, encompassing diet, fitness, and mental wellness, on improving glycemic control in T2D.Methods: This interim analysis was conducted on 34 participants (HbA1c >8%) compared the test group (n=18) […]

Introduction and Objective: Epidemiological and genetic studies have shown that disruption of circadian rhythms leads to accelerated and worsened symptoms of metabolic syndrome. Studies indicate that core clock factor, BMAL1, is required for insulin-dependent skeletal muscle glucose uptake in lean mice. However, the role of the clock in skeletal muscle metabolism during metabolic stress is […]

Introduction and Objective: The cardio-renoprotective properties of sodium-glucose cotransporter-2 (SGLT-2) inhibitors, angiotensin receptor blockers (ARBs), and angiotensin-converting enzyme (ACE) inhibitors are well-documented; however, their effectiveness in primary prevention among individuals with diabetes mellitus and hypertension, without preexisting cardiovascular (CV) or kidney disease, remains uncertain. This study evaluates the potential synergistic benefits of combining SGLT-2 inhibitors […]

Introduction and Objective: Adipose tissue (AT) is a central regulator of energy homeostasis and systemic metabolism. Dysfunctional AT expansion during obesity is a major driver of metabolic diseases, particularly type 2 diabetes. Mesenchymal progenitor cells (MPCs), a heterogeneous and dynamic cell population, play a critical yet poorly understood role in AT expansion and function. In […]

Introduction and Objective: The American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) recommend glucagon-like peptide-1 receptor agonists (GLP1-RA) for type 2 diabetes, but their use in type 1 diabetes (T1D) is limited. This study compared glycemic metrics and adverse events in fasting and non-fasting people with T1D using GLP1-RA during […]

Introduction and Objective: ALK7 plays a crucial role in adipose homeostasis, with genetic variants linked to obesity in human GWAS. This study examines the pharmacodynamic effects of SGB-ALK7 in cynomolgus monkeys and its therapeutic potential in an obese mouse model.Methods: SanegeneBio is developing Ligand and Enhancer Assisted Delivery (LEAD™) technology, which utilizes a receptor-mediated internalization […]

Introduction and Objective: The prevalence of type 1 diabetes (T1D) in older adults has increased over the last few decades. Many aspects of self-care may be impacted by age related changes, comorbidities, and risk of hypoglycemia. Yet, few studies have characterized the emotional burden of diabetes distress (DD) in this age group and its clinical […]