Category: Diabetes

Introduction and Objective: Diabetic Kidney Disease (DKD) occurs commonly in people with diabetes and often presents with albuminuria resulting from glomerular filtration barrier injury. The glycocalyx, an extracellular matrix (ECM) produced by endothelial cells, plays a critical role in regulating glomerular filtration.Methods: To test if diabetes induces ECM changes, we examined the abundance of glomerular […]

Introduction and Objective: To explore the incidence of emergency hospitalization among young-onset diabetes using a nationwide registry database.Methods: Based on the Korean National Health Insurance Service-National Sample Cohort database from 2006 to 2019, data were collected for patients aged ≤30 years with type 1 (T1D) and type 2 diabetes (T2D). The risks of emergency hospitalization […]

Introduction and Objective: Individuals who carry genetic variants that lower A1C independently of glycemia may have undetected hyperglycemia. Other glycated proteins can be used as alternate glycemic measures but whether these A1C variants affect their levels is unclear.Methods: We recalled 202 patients (10% diabetes) from the Mass General Brigham Biobank enriching recruitment for the African […]

Introduction and Objective: Large-scale, real-world data on age- and sex-specific Level 3 hypoglycemia rates in type 1 or 2 diabetes (T1D, T2D) remain critically sparse. We aimed to address this gap using prospective data from the iNPHORM study.Methods: Adults (≥18 years) with T1D or T2D on insulin and/or secretagogues recruited from a US-wide probability-based internet […]

Introduction and Objective: Managing carbohydrate intake and physical activity (PA) are recommended for individuals with pregnancy hyperglycemia, but the concurrent impact of these behaviors and meal timing on postprandial glucose levels has not been explored.Methods: Fourteen participants with gestational glucose intolerance (GGI) and 2 with GDM from the Time to Move Randomized Crossover Trial (ClinicalTrials.gov […]

Introduction and Objective: Glycated hemoglobin (HbA1c) is the primary clinical measure of average glucose (AG). The X-linked G6PD variant has been associated with lower HbA1c but higher complication risks; yet the extent to which the variant impacts the HbA1c-AG relationship resulting in undetected hyperglycemia is unclear.Methods: In the GRADE Study, 1287 participants with type 2 […]

Introduction and Objective: Extracellular vesicles (EVs) are small membrane-bound particles secreted by cells, playing a crucial role in intercellular communication and cellular homeostasis.Methods: Human EndoC βH1 beta cells were obtained from Human Cell Design. To assess impacts of EV transfer on recipient cells, small EVs from cells treated with or without a cytokine mix were […]

Introduction and Objective: Metals may increase the risk of GDM, while certain elements may be protective. We examined the associations of a mixture of metals and elements during pregnancy with GDM risk in a predominantly Black and Hispanic cohort.Methods: In the Boston Birth Cohort, we measured Pb, Hg, Cd, Se, and Mn in maternal red […]

Introduction and Objective: Low carbohydrate diets (LCDs) are used by some living with T1D due to perceived glycemic benefits. Yet, few randomized controlled trials have studied LCDs in youth with T1D.Methods: Youth (12-25y) with T1D enrolled in a randomized crossover study to follow a LCD (<15% calories from carbs) and a standard carbohydrate diet (SCD, […]

Introduction and Objective: C414A-CRY1 transgenic mice (TG) develop diabetes due to SASP-like phenotypes in β-cells. We demonstrated that mucinous intra-islet ductal cells (IIDCs) expressing TFF2, that is known as a marker of spasmolytic polypeptide-expressing metaplasia (SPEM) in the stomach, emerge age-dependently in TG. Reportedly, acinar to ductal metaplasia (ADM) occurs through a process similar to […]