Category: Diabetes

“I’m a scientist, and as a scientist, as you learn things, you realize there’s so much more that we don’t know. Answers just lead to more questions,” Rebecca Haeusler says. “We still have so much to learn about how the human body works.” Source link

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Bundesministerium für Bildung und Forschung10.13039/50110000234701GI0925 Source link

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]

In this special episode on Strategies for Staying Full and Satisfied, our host, Dr. Neil Skolnik will moderate a discussion with Lily Correa, registered dietitian about communicating strategies for staying full and satisfied. This special edition of Diabetes Core Update is sponsored by Avocados – Love One Today ®.    For more information, as well as […]

This study compares novel type 1 diabetes–related autoantibody assays developed to improve upon the standard radiobinding assay (RBA). Samples from 1,505 individuals, followed for 5 years or to clinical type 1 diabetes, originally tested by RBA were aliquoted and sent blindly to five laboratories (Barbara Davis Diabetes Center [BDC], Institute of Diabetes Research [IDR], Diabetes […]

Obesity-induced biologic changes often persist after weight loss and are difficult to reverse, a phenomenon known as obesogenic memory. This enduring effect is associated with metabolic inflammation, particularly in adipose tissue. In this study, we characterized a mouse model of obesogenic memory and evaluated the efficacy of the unimolecular conjugate glucagon-like peptide 1 (GLP-1)/dexamethasone (GLP-1/Dexa), […]

Type 1 diabetes (T1D) results from a complex dialogue between the immune system and islets characterized by T cell–mediated autoimmune destruction of pancreatic β-cells. In this dialogue, β-cell stress responses have emerged as drug targets for slowing T1D progression, including a subpopulation of senescent β-cells that accumulate during T1D in humans and nonobese diabetic (NOD) […]

Evidence of retinal vascular inflammation accompanies diabetic retinopathy (DR) progression, and inflammatory cytokines tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β) are experimentally linked to several hallmark DR features, including retinal leukostasis. Cannabinoid receptor 2 (CB2) agonism has been shown to decrease inflammatory cytokine production and leukocyte recruitment and adhesion in nonocular inflammation models, suggesting CB2 […]

Impaired cardiac ketone oxidative capacity is a possible disease mechanism in the development of diabetic cardiomyopathy. We examined whether the cardiovascular effects of ketone bodies are different in patients with type 1 diabetes (T1D) compared with healthy control individuals. In a single-blind study with a crossover design, nine patients with T1D and eight age-matched, healthy […]