This year marks the 75th anniversary of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health. NIDDK’s long history of research and innovation includes support of four types of collaborative research centers focused on diabetes, endocrinology, and metabolic diseases. The Diabetes Research Centers promote basic and clinical […]
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Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data
In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this research has been the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), most recently through the Accelerating Medicines Partnership Program for Type 2 Diabetes (AMP T2D) and Accelerating Medicines […]
Read MoreMapping Macrophage-Fibroblast Interactions in Adipose Tissue Fibrosis
National Research Foundation of Korea (NRF)NRF-2020R1A3B2078617RS-2023-00218616RS-2024-00460865 Source link
Read MoreDeciphering Macrophage-Fibroblast Cross Talk in Obesity-Induced Adipose Tissue Fibrosis: Insights From Single-Cell and Spatial Transcriptomics
The study by Kohda et al. (1) in this issue of Diabetes is a remarkable contribution to the field of adipose tissue biology and metabolic research. The authors have used cutting-edge single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to dissect the intricate cellular interactions within adipose tissue during obesity-induced fibrosis. Their identification of novel cell-to-cell communications […]
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Read MoreDiabetes Spotlight: Carmella Evans-Molina, MD, PhD—Charting β-Cell Dysfunction to Delay the Onset of Type 1 Diabetes
Growing up, Carmella Evans-Molina felt there were limited options for a girl in West Virginia coal country. She grew up in the shadow of Kopperston Mountain, living, until age 4, in a row house in an old coal camp—“rows and rows of houses that all looked the same,” she says—the vestige of a company town. […]
Read MoreDiabetes Core Update : Special Edition: Myth Busters
In this special episode on Fish Oil – Facts, Fiction, and EPA our host, Dr. Neil Skolnik, will discuss the evidence distinguishing fish oil from EPA (Icosapent ethyl). This special episode is supported by an independent educational grant from Amarin. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, […]
Read MoreDiabetes Core Update June 2025
Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreThe Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans
Small glycemic increments (≤0.5 mmol/L) can exert suppressive actions on endogenous glucose production (EGP); however, it is unclear if this is an insulin-dependent or -independent process. Here, we performed a low-rate glucose infusion in control participants without diabetes and in people with type 1 diabetes (T1D) to better understand this phenomenon. Glucose kinetics, hormones, and […]
Read MoreType 1 Diabetes Depends on CD4-Driven Expression of the Transcriptional Repressor Bcl6
High-affinity islet autoantibodies predict type 1 diabetes in mice and humans and implicate germinal centers (GCs) in disease pathogenesis. T follicular helper (Tfh) cells are increased in individuals with type 1 diabetes and alterations in Tfh-like cells in the peripheral blood predicted individual responses to abatacept. Tfh cells support GC responses and depend on the […]
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