Introduction and Objective: The AABBCC approach (Age <35 years, Autoimmunity [family or personal history], BMI <25 kg/m2, Background, Control [not responding to oral agents], and Comorbidities) has been proposed by the American Diabetes Association to help distinguish between diabetes types. This study examined the reclassification rates from prediabetes or type 2 diabetes (T2D) to type […]
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1554-P: Barriers to Treatment Adherence among Latino Adults with Type 2 Diabetes: Baseline Findings from the REACH-Es Pilot Study
Introduction and Objective: Suboptimal diabetes medication adherence disproportionately affects Latino adults with type 2 diabetes (T2D). REACH is a text messaging platform based on the Information-Motivation-Behavioral skills model that addresses barriers to medication adherence. REACH was adapted into Spanish (REACH-Español) and is being evaluated in a 6-month pilot RCT among 70 Latino adults with T2D. […]
Read More2230-P: Profile of Monogenic Diabetes in a Predominantly Hispanic Pediatric Population: Insights from a Single-Center Cohort
Introduction and Objective: Maturity Onset Diabetes of the Young (MODY) is an underrecognized and misdiagnosed form of diabetes that refers to a group of single gene causes of diabetes with a strong autosomal dominant inheritance. Fourteen (14) gene mutations have been identified accounting for 1-5% of all diabetes cases. Identification of MODY is necessary for […]
Read More1657-P: Concomitant Use of GLP-1RAs and Chronic Opioids and Risk of Opioid Overdose and Substance Use Disorders
Introduction and Objective: Chronic opioid use is associated with high risk of overdose and developing substance use disorder. GLP-1RAs may influence reward-related neurobehavioral pathways, however, their real-world effects on opioid-related outcomes are unclear. We evaluated the association between GLP-1RA use and risk of opioid overdose among individuals with chronic opioid use.Methods: Using US claims data, […]
Read More2229-P: Association between C-Reactive Protein–Triglyceride–Glucose Index and New-Onset Chronic Disease Incidence and Mortality: Evidence from Multinational Cohorts
Introduction and Objective: The C-reactive protein-triglyceride-glucose index (CTI) is a composite biomarker reflecting insulin resistance and systemic inflammation. Large-scale evidence linking CTI to multiple chronic diseases and cause-specific mortality remains limited.Methods: We conducted a multicenter cohort study of middle-aged and older adults using the China Health and Retirement Longitudinal Study (CHARLS, n=5366) and US National […]
Read More2612-P: AI/ML-Driven Genetic Discovery through In Vivo Validation of Obesity Targets
Introduction and Objective: Brown adipose tissue (BAT) plays a key role in non-shivering thermogenesis and is strongly implicated in obesity and metabolic disease, and may offer an alternative therapeutic strategy for treating obesity and its related comorbidities.Methods: Starting from a BAT-ML (an in-house machine learning (ML)-derived BAT phenotype) GWAS, we investigated the relevance of these […]
Read More3063-LB: Acipimox Normalizes Proinflammatory Serum Lipidomic Dysregulation Produced by Electronic Cigarette in a Diet-Induced Obesity Mouse Model
Introduction and Objective: Electronic cigarettes (e-cigs) have become the main tobacco product used by youth. Although the effects of conventional cigarette use have been studied, the metabolic effects of e-cigs have yet to be explored. In mice on a high-fat diet (HFD), we have shown that e-cig treatment produces cardiac dysfunction in a lipolysis-dependent manner. […]
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What Influencers Aren’t Telling You About the Risks
Share on PinterestInfluencers tout peptide injections for fitness and longevity, but experts warn of health and safety risks. Mariya Borisova/Getty Images Injectable “wellness” peptides have become wildly popular among health and wellness enthusiasts, despite lacking credible evidence for their safety and effectiveness. Social media influencers and biohackers tout wellness peptides as a “fountain of youth” […]
Read More3064-LB: Mitochondrial Protonophore TLC-1180 Mitigates Cognitive Decline in Diet-Induced Obese Mice
Introduction and Objective: Obesity and type 2 diabetes are strongly associated with accelerated cognitive decline. We tested whether chronic high-fat diet (HFD) feeding with sucrose intake impairs cognition in mice and whether TLC-1180, a novel mitochondrial protonophore, improves metabolic and neural deficits.Methods: Male C57BL/6J mice were fed regular chow (RC) or HFD with 1% sucrose […]
Read More3065-LB: Nonclinical Profile of AMB-702, a Potent and Novel Oral GLP-1 Receptor Agonist
Introduction and Objective: Oral, small-molecule GLP-1RA receptor agonists hold significant promise to provide durable weight loss and improved long-term outcomes for those living with obesity, Type 2 diabetes or other chronic cardiometabolic disorders. The objective of this research was to demonstrate the differentiated profile of the oral GLP-1 receptor agonist and development candidate, AMB-702, with […]
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