When dairy farmer Brie Hyde began experiencing chronic fatigue and joint pain, doctors treated her for Lyme disease. After years of worsening symptoms, she was diagnosed with Lupus. As a child, Brie Hyde dreamed of being a veterinarian. “I’ve always been an outdoorsy person, very animal fascinated,” she told Healthline. While attending the University of […]
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Share on PinterestResearch shows that perimenopause may be the ideal time to adopt lifestyle changes to help lower cardiovascular risks. Image Credit: Aleksandar Nakic/Getty Images A recent study suggests that perimenopause offers a “window of opportunity” for females to reassess cardiovascular risk and prompt lifestyle changes. The findings show that perimenopausal females may be two […]
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Share on PinterestResearchers say current aerobic exercise recommendations may not be sufficient to reduce cardiovascular risk. MoMo Productions/Getty Images Researchers say adults may need to quadruple the current weekly exercise recommendations to achieve substantial heart health benefits. Those with lower levels of fitness may need as much as 600 minutes of weekly aerobic activity to […]
Read MoreWeight cycling has been demonstrated, in humans and animal models, to increase cardiometabolic disease and disrupt glucose homeostasis. Both obesity itself and weight cycling cause adipose tissue inflammation and metabolic dysfunction. Studies show that even after weight loss, increased numbers of lipid-associated macrophages and memory T cells persist in adipose tissue and become more inflammatory […]
Read MoreDiabetic cardiomyopathy (DCM), characterized by myocardial hypertrophy and fibrosis, is a severe complication of diabetes. Activation of Yes-associated protein (Yap) has been implicated in myocardial remodeling and cardiac dysfunction. This study aimed to elucidate the role and underlying molecular mechanisms of Yap in DCM. Yap expression was evaluated in mice with type 2 diabetes mellitus […]
Read MoreMetabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health or reversing established PN is less clear. First, in a maintenance paradigm, we […]
Read MoreAn inflection point (IP) marking accelerated β-cell decline occurs ∼1–2 years before type 1 diabetes diagnosis. Precisely determining this timing could optimize clinical intervention. We developed machine learning models to predict proximity to the inferred metabolic IP using oral glucose tolerance test (OGTT) data from islet autoantibody-positive individuals in the TrialNet Pathway to Prevention study. […]
Read MoreThe naturally occurring peptide, liver-expressed antimicrobial peptide 2 (LEAP2), has gained interest as a ghrelin receptor antagonist. We previously reported reduced food intake and plasma glucose–lowering effects of LEAP2 infusion in lean healthy men; however, the effects of this competitive antagonist and inverse agonist of the ghrelin receptor in men with obesity have not been […]
Read MoreDiabetes-related vascular complications are characterized by impaired ischemia-driven angiogenesis and delayed wound healing. MicroRNAs (miRNAs) are emerging as powerful targets for multifaceted diseases. We previously identified that miRNA-181c-5p has anti-angiogenic properties, but its role in diabetes is unknown. In a hindlimb ischemia model, streptozotocin-rendered diabetic mice treated with an miRNA-181c-5p inhibitor (anti–miR-181c-5p) exhibited improved blood […]
Read MorePhosphoglucomutase 1 (PGM1) is a type 1 diabetes susceptibility gene that potentially plays a key role in regulating central carbon metabolism in β-cells. Previous work suggested that β-cell PGM1 transcription is lowered after coxsackievirus B4 infection. Thus, we hypothesized that decreased PGM1 levels disrupt β-cell metabolic homeostasis and result in β-cell fragility and type 1 […]
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