Author: sugaradmin

Introduction and Objective: People living with type 1 diabetes (pwT1D) are at risk for micro and macrovascular complications, mental health issues, as well as higher risk for additional autoimmune diseases (AD+). We aimed to understand the association between additional ADs and T1D related physical and mental burdens in Canadian adults.Methods: This was a cross-sectional study […]

Introduction and Objective: Glucagon influences glucose tolerance by increasing nutrient-induced insulin secretion. After gastric bypass (GB), prandial glucagon levels rise, independent of the nutrient composition, and remain elevated in the latter phase of the meal, when glycemia dips below fasting level. Here, we investigated the effect of hyperglucagonemia (100-150 pg/ml), created by ‘exogenous glucagon infusion’, […]

Introduction and Objective: Studies suggest weight gain in type 1 diabetes (T1D) may parallel that of adults without diabetes. The impact of this on cardiometabolic risk factors in T1D is less known.Methods: Veterans with T1D in the Veterans Health Administration from January 1, 2022 to December 31, 2023 had BMI calculated using averaged heights and […]

Introduction and Objective: Food insecurity (FI), a lack of consistent access to nutritionally adequate and safe food, affects more than 10% of Americans. FI is associated with adverse health outcomes including obesity and diabetes, but there is limited data about the impact of FI in pregnancy. Our objective was to determine the association between maternal […]

Introduction and Objective: While many individuals with Type 1 Diabetes (T1D) are typically exempt from fasting for health reasons. In this context, the Glycemia Risk Index (GRI) is a valuable tool for assessing glycemic quality. This study investigates the effects of Ramadan fasting on glycemic control in T1D, focusing on GRI and its components for […]

Introduction and Objective: The catalytic (NKAα1) and auxiliary (NKAβ1) subunits of the NKA protein complex are highly expressed in α-cells, yet their influence is poorly understood. Given the importance of NKA to cation handling and membrane potential regulation, we aimed to define the role of NKA in tuning α-cell Ca2+-handling and glucagon secretion.Methods: Electrophysiology, fluorescence […]

Introduction and Objective: MODY is estimated to account for 1-2% of all diabetes cases, with HNF1A-MODY being the most common subtype. While most studies have focused on Europe and North America, this study analyzes HNF1A mutation data and examines the clinical characteristics of Asian individuals with HNF1A-MODY.Methods: We collected data from 38 studies on Asian […]

Introduction and Objective: Type 2 Diabetes (T2D) shortens lifespan largely via increased CVD risk. Cardiorespiratory fitness (CRF), a strong predictor of CVD mortality, is lower in people with T2D. Our previous work showed lower muscle oxidative flux in vivo in T2D compared to overweight controls, despite similar ex vivo mitochondrial oxygen consumption. Supplemental oxygen or […]

Introduction and Objective: Emerging evidence demonstrates the presence of neurocognitive impairment and lower brain volume in youth with type 2 diabetes (T2D) and obesity compared to peers. Resting-state functional magnetic resonance imaging (rsfMRI) offers non-invasive assessment of brain function and established brain networks. Multimodal imaging integration, such as brain structure and function, may better elucidate […]

Introduction and Objective: Evaluate the additional role of Finerenone (Fi) on renal markers (RM) in T2DM patients with diabetic nephropathy (DN) Stages 1-3, receiving angiotensin receptors blocker (ARB) [Valsartan {V} or Telmisartan {Tm}], SGLT2i (dapagliflozin) {D} & optimized for Blood Pressure (BP) <130/80mm for at least 1 yr.Methods: Between Oct’ 22 & Mar’ 23, 60 […]