Insulin regulates glucose uptake and metabolism in muscle via the insulin receptor. Here, we show that Lrtm1 (leucine-rich repeat and transmembrane domain 1), a protein of unknown function enriched in insulin-responsive metabolic tissues, senses changes in insulin signaling in muscle and serves as a regulator of metabolic response. Thus, whole-body Lrtm1-deficient mice exhibit a reduced […]
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Alterations of hepatic lipid content following COVID-19 in persons with type 2 diabetes
Baseline characteristics Anthropometric data of both groups were comparable except for nominally higher percentage of females and higher high-density lipoprotein-cholesterol in the COVID-neg group (table 1). Table 1 View inline•Open as popup Participants’ characteristics at baseline Follow-up after COVID-19 None of the participants of the COVID-pos group had severe COVID-19 according to the classification by […]
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Vaccines Don’t Cause Autism. Here’s What Might, According to Science
Share on PinterestDespite a unanimous scientific consensus, health experts are once again defending the safety of childhood vaccines and so-called autism risk. Sean Locke/Stocksy United The CDC will conduct research to determine if there is any link between childhood vaccinations and autism risk. Health experts have long said there is no substantial scientific evidence to […]
Read MoreRoot Causes of Obesity, Sugar and Highly Processed Carbs – November 2024
In this special episode on Root Causes of Obesity, Sugar and Highly Processed Carbs, our host, Dr. Neil Skolnik will discuss Root Causes of Obesity, Sugar, and Strategies to Decrease Sugar in the Diet with three experts in field – a nutrition epidemiologist, a public health expert and a registered dietician. This special episode is […]
Read MoreCanagliflozin-Induced Adaptive Metabolism in Bone
Sodium–glucose transporter-2 inhibitor (SGLT2i) drugs are widely used for lowering blood glucose levels independent of insulin. Beyond this, these drugs induce various metabolic changes, including weight loss and impaired bone integrity. A significant gap exists in understanding SGLT2i-induced skeletal changes, as SGLT2 is not expressed in osteoblasts or osteocytes, which use glucose to remodel the […]
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Predicting diabetes self-management education engagement: machine learning algorithms and models
Discussion This study demonstrated excellent predictive capabilities for DSME engagement through the utilization of ML models. Among the ML models evaluated, our results indicated that RF has the best performance for DSME prediction, with an AUC of 94% and an accuracy of 85%. Additionally, we identified 74 of 95 variables as key variables, and racial/ethnic […]
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TB Cases Rising Globally, Who Says. Should the US Be Worried?
Share on PinterestExperts say a rise in TB cases in Europe could mean a future surge in cases in the United States. AscentXmedia/Getty Images The WHO reports that the number of tuberculosis cases in children is rising in Europe. The health officials add that the treatment success rate for the disease is also well below […]
Read MoreDiabetes Core Update December 2024
Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]
Read MoreComparison of the Effects of SGLT-2i Versus GLP-1RA on Cardiovascular and Renal Outcomes in Patients With Type 2 Diabetes, Based on Baseline Renal Function
Finding no head-to-head research evaluating the cardiovascular and renal benefits of sodium–glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) in patients with type 2 diabetes (T2D) at different baseline renal function, we performed a network meta-analysis to compare the two drugs indirectly. Systematic literature searches were conducted of the PubMed, Cochrane […]
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Role of 2-hour plasma glucose in assessing pre-diabetes risk: insights from the vitamin D and type 2 diabetes (D2d) study cohort
Historically, an elevated level of 2-hour plasma glucose (2hPG) during a 75-gram oral glucose tolerance test (OGTT) was the hallmark of pre-diabetes. This measurement served as a primary criterion in pivotal diabetes prevention clinical trials, including the Diabetes Prevention Program.1 However, with the American Diabetes Association (ADA) expanding its diagnostic criteria for pre-diabetes in 2010 […]
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