Conclusions Over the course of 2 years, we developed, tested, and validated the DISDOH. The DISDOH is a concise 16-item assessment that provides an overview of the ADA’s five critical SDoH factors influencing individuals with diabetes: socioeconomic status, neighborhood and physical environment, food environment, healthcare access, and social context. No similar measure exists presently. We […]
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Influence of metabolism-related comorbidities and insulin resistance on new onset of chronic kidney disease in a health check-up population: a two-stage retrospective cohort study
Discussion Our study showed that the average eGDR was significantly higher in the non-CKD group than in the CKD group, suggesting reduced insulin sensitivity in individuals with CKD. A follow-up study further identified a significant association between decreased insulin sensitivity and new-onset CKD, which was particularly pronounced in individuals without diabetes and those with higher […]
Read MoreGlucose absorption in the duodenum is modulated by an estrogen receptor α-dependent regulation of glucose transporter functional expression
Materials and methods Oral glucose tolerance test in human participants Healthy Chinese women aged 20–30 years with regular menstrual cycles (menstrual period within 3–7 days, menstrual cycle in the range of 25–32 days) and without lesions or medical conditions causing irregular menstruation were included. Research on healthy human volunteers was conducted in accordance with the principles […]
Read MoreHow Running Marathons Helps These Sisters Manage Their Prediabetes
Share on PinterestSister content creators Issa (left) and Nadya Okamoto say training for marathons helps them manage their prediabetes. Photography by Nadya and Issa Okamoto Sister content creators Issa and Nadya Okamoto share their recent diagnoses with prediabetes. The sisters started running and training for marathons as a way to combat the condition. The Okamotos […]
Read MoreHulk Hogan Dead at 71 Following Cardiac Arrest
Share on PinterestHulk Hogan has passed away after experiencing cardiac arrest, reportedly following weeks of declining health. Paul Kane/Getty Images Wrestling icon Hulk Hogan reportedly had heart-related health issues for years before dying after experiencing cardiac arrest this week. Heart disease remains the leading cause of death in the United States, with obesity, smoking, unhealthy […]
Read MoreGLP-1 Drugs Like Ozempic, Wegovy May Cause Dehydration, Experts Say
Share on Pinterest The hunger-reducing mechanisms of GLP-1 drugs, as well as their side effects, may contribute to dehydration. Edwin Tan/Getty Images Experts say people who take GLP-1 weight loss medications should stay hydrated, particularly when temperatures are high. The mechanisms of GLP-1 drugs that help reduce appetite, as well as their side effects, may […]
Read MoreOzzy Osbourne Lived with Parkinson’s for Years Before Death at 76
Share on PinterestRock legend Ozzy Osbourne shared the health challenges he faced living with Parkinson’s disease in the years before his death at 76. Harry How/Getty Images The effects of Parkinson’s disease are back in the spotlight after the death of singer Ozzy Osbourne. Experts say Parkinson’s can cause a wide variety of health issues, […]
Read MoreEvaluating GLP-1 receptor agonists versus metformin as first-line therapy for reducing dementia risk in type 2 diabetes
Discussion This study represents the first and largest direct comparison of GLP-1 RAs and metformin in mitigating dementia risk among patients with T2DM. Historically, metformin has been the cornerstone of first-line therapy for T2DM due to its well-established efficacy in glycemic control and its potential neuroprotective effects.20–28 However, whether initiating GLP-1 RAs as first-line therapy […]
Read MoreAlkaline, Electrolyte, or Tap? Experts on the Best Water for Hydration
Share on PinterestDespite the popularity of trendy alkaline or electrolyte-infused waters, regular tap water can also help you stay sufficiently hydrated. Ekaterina Goncharova/Getty Images Proper hydration is essential for health, especially during the hot summer months. Alkaline or electrolyte-infused waters are often touted for their purported health benefits, but experts say tap water is cheaper […]
Read MoreFunctional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes
Glucokinase (GK) activators (GKAs) are a long-sought therapeutic modality for the treatment of type 2 diabetes. However, GKAs have failed in clinical trials, with the recent exception of dorzagliatin (Hua Medicine). A comprehensive approach using human islet perifusions, enzyme kinetics, X-ray crystallography, and modeling studies was applied to compare the effects of dorzagliatin with those […]
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