Introduction and Objective: Brown adipose tissue (BAT) plays a key role in non-shivering thermogenesis and is strongly implicated in obesity and metabolic disease, and may offer an alternative therapeutic strategy for treating obesity and its related comorbidities.Methods: Starting from a BAT-ML (an in-house machine learning (ML)-derived BAT phenotype) GWAS, we investigated the relevance of these genetic signals in vitro using human adipocyte cell models and in vivo in HFD obese mice.Results: At least 1 target identified through BAT-ML was found to reduce body weight and fat mass AND increased BAT/beige-like character in vivo.Conclusion: Here, we present the first BAT-ML GWAS and prosecution of the genetic insights in adipocyte cell models through in vivo validation in support of targeting BAT for potentially treating obesity and its related comorbidities.
J. Choy: Employee; Current; insitro. Employee; Ended; Maze Therapeutics. Stock/Shareholder; Current; Maze Therapeutics, Merck & Co., Inc. D. Lloyd: None.
Source link
Leave a Reply