Introduction and Objective: The incidence of gastrointestinal cancers in type 1 diabetes (T1D) patients is higher than in the general population. This study aimed to explore the association between T1D and gastrointestinal cancer, and how it varies by age and sex.Methods: This retrospective cohort study included 268,179 participants from Korean National Health Insurance Service-National Sample Cohort. The primary outcome is the incidence of gastrointestinal cancers, based on diagnostic codes. Multivariate Cox regression analyses assessed the association between T1D and gastrointestinal cancers.Results: Of the participants, 2681 had T1D at baseline and were followed for an average of 12.98 years. T1D patients had a significantly increased risk of gastrointestinal cancer (adjusted hazard ratio [aHR]: 1.403, 95% confidence interval [CI]: 1.253-1.573), including esophageal cancer (aHR: 1.864, 95% CI: 1.038-3.349), gastric cancer (aHR: 1.313, 95% CI: 1.066-1.616), colon cancer (aHR: 1.365, 95% CI: 1.110-1.678), liver cancer (aHR: 1.388, 95% CI: 1.115-1.727), and pancreatic cancer (aHR: 1.716, 95% CI: 1.182-2.492). The association was consistent among both males and females and increased with age.Conclusion: The risk of gastrointestinal cancer is significantly higher in T1D patients, especially older males, indicating a need for targeted care.
D. Lee: None. J. Ryoo: None.
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