Introduction and Objective: The type 2 diabetes susceptibility gene GPSM1 is linked to impaired muscle function in patients, though its molecular mechanisms remain unknown. This study explores how GPSM1 regulates skeletal muscle metabolism and motor performance.Methods: Skeletal muscle-specific GPSM1 knockout (GPSM1MKO) mice were generated and maintained on either a standard chow or high-fat diet (HFD), […]
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2762-LB: Type 2 Diabetes Remission Rate and Change in Medication Burden after 12 Months of Intermittent Fasting
by sugaradmin
Introduction and Objective: Intermittent energy restriction (IER) and time-restricted eating (TRE) are two forms of intermittent fasting that may reduce diabetes medication needs in type 2 diabetes (T2D). However, head-to-head comparisons of IF approaches and trials using IF in T2D remain limited. We evaluated diabetes remission and pharmacologic de-intensification in a secondary analysis of a […]
Read More2232-P: Multiomics Integration Identifies Distinct Molecular Endotypes of Atypical Diabetes
by sugaradmin
Introduction and Objective: A convergence of dysregulated metabolic, polygenic and environmental factors drives the pathophysiology of diabetes mellitus. We performed unsupervised integration of transcriptomic and metabolomic data among participants in the Rare and Atypical Diabetes Network (RADIANT) to identify distinct endotypes of atypical diabetes.Methods: This cross-sectional, observational study included RADIANT participants meeting predefined atypical diabetes […]
Read More2521-P: Physical Inactivity Induced by Bed Rest Reduces Muscle but Not Hepatic or Adipose Tissue Insulin Sensitivity in Older Adults with or without Pre- or Type 2 Diabetes
by sugaradmin
Introduction and Objective: Older adults with pre-diabetes or type 2 diabetes experience hospitalization and bed rest more frequently than healthy older adults. However, the impact of physical inactivity induced by bed rest on insulin sensitivity in older adults with pre- or type 2 diabetes is unknown. To address this, we conducted a 10-day bed rest […]
Read More2231-P: RECLASS-T1D: Real-World Evaluation of AABBCC Criteria for Diabetes Classification: Experience from 6.7 Million U.S. Patients
by sugaradmin
Introduction and Objective: The AABBCC approach (Age <35 years, Autoimmunity [family or personal history], BMI <25 kg/m2, Background, Control [not responding to oral agents], and Comorbidities) has been proposed by the American Diabetes Association to help distinguish between diabetes types. This study examined the reclassification rates from prediabetes or type 2 diabetes (T2D) to type […]
Read More1554-P: Barriers to Treatment Adherence among Latino Adults with Type 2 Diabetes: Baseline Findings from the REACH-Es Pilot Study
by sugaradmin
Introduction and Objective: Suboptimal diabetes medication adherence disproportionately affects Latino adults with type 2 diabetes (T2D). REACH is a text messaging platform based on the Information-Motivation-Behavioral skills model that addresses barriers to medication adherence. REACH was adapted into Spanish (REACH-Español) and is being evaluated in a 6-month pilot RCT among 70 Latino adults with T2D. […]
Read More2230-P: Profile of Monogenic Diabetes in a Predominantly Hispanic Pediatric Population: Insights from a Single-Center Cohort
by sugaradmin
Introduction and Objective: Maturity Onset Diabetes of the Young (MODY) is an underrecognized and misdiagnosed form of diabetes that refers to a group of single gene causes of diabetes with a strong autosomal dominant inheritance. Fourteen (14) gene mutations have been identified accounting for 1-5% of all diabetes cases. Identification of MODY is necessary for […]
Read More1657-P: Concomitant Use of GLP-1RAs and Chronic Opioids and Risk of Opioid Overdose and Substance Use Disorders
by sugaradmin
Introduction and Objective: Chronic opioid use is associated with high risk of overdose and developing substance use disorder. GLP-1RAs may influence reward-related neurobehavioral pathways, however, their real-world effects on opioid-related outcomes are unclear. We evaluated the association between GLP-1RA use and risk of opioid overdose among individuals with chronic opioid use.Methods: Using US claims data, […]
Read More2229-P: Association between C-Reactive Protein–Triglyceride–Glucose Index and New-Onset Chronic Disease Incidence and Mortality: Evidence from Multinational Cohorts
by sugaradmin
Introduction and Objective: The C-reactive protein-triglyceride-glucose index (CTI) is a composite biomarker reflecting insulin resistance and systemic inflammation. Large-scale evidence linking CTI to multiple chronic diseases and cause-specific mortality remains limited.Methods: We conducted a multicenter cohort study of middle-aged and older adults using the China Health and Retirement Longitudinal Study (CHARLS, n=5366) and US National […]
Read More2612-P: AI/ML-Driven Genetic Discovery through In Vivo Validation of Obesity Targets
by sugaradmin
Introduction and Objective: Brown adipose tissue (BAT) plays a key role in non-shivering thermogenesis and is strongly implicated in obesity and metabolic disease, and may offer an alternative therapeutic strategy for treating obesity and its related comorbidities.Methods: Starting from a BAT-ML (an in-house machine learning (ML)-derived BAT phenotype) GWAS, we investigated the relevance of these […]
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