Introduction and Objective: The protein kinase A (PKA) signaling cascade is the core signaling pathway of hepatic gluconeogenesis. However, the mechanisms governing PKA nuclear translocation remain incompletely understood. In this study, we identified the nuclear membrane protein TMEM201 (transmembrane protein 201) as a critical regulator of PKA nuclear translocation.Methods: PKA catalytic subunits were used as […]
Read MoreMonth: June 2026
1286-OR: FiberMore: A Generative AI-Enabled Behavior Change Intervention to Improve Dietary Fiber Intake and Glycemic Management in Individuals with Type 2 Diabetes
Introduction and Objective: A high intake of dietary fiber has been shown to improve glycemic management in individuals living with Type 2 diabetes (T2D). We developed FiberMore, a generative AI-based mobile app grounded in the Theory of Planned Behavior, to address inadequate fiber intake in individuals with T2D, and assessed its efficacy in increasing fiber […]
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Shaquille O’Neal Shares How Zepbound Helped with Sleep Apnea and Weight Loss
Share on PinterestNEW YORK, NEW YORK – MAY 12: Shaquille O’Neal attends the 2026 Disney Upfront at Jacob K. Javits Convention Center on May 12, 2026 in New York City. (Photo by John Nacion/FilmMagic) Shaquille O’Neal is taking Zepbound to help manage his weight and reduce obstructive sleep apnea (OSA) symptoms. Zepbound is FDA approved […]
Read More1316-OR: Prevention of Cellular Senescence and EMT Enables Expansion of Human Pluripotent Stem Cell–Derived Pancreatic Endoderm Cells
Introduction and Objective: Human pluripotent stem cell-derived pancreatic β-like cells (hPSC-β cells) represent a promising cell source for diabetes therapy. However, their clinical translation is hampered by time- and cost-intensive differentiation protocols. Establishing a scalable expansion system for hPSC-derived pancreatic endoderm (progenitor) cells (hPSC-PEs) would enable accessible regenerative therapies.Methods: To identify the mechanisms limiting their […]
Read More1339-OR: Learning from a Single CGM Use: The Impact of Professional, Supplemental Education in Non-Insulin Treated Type 2 Diabetes
Introduction and Objective: Short-term use of a single stand-alone 14-day continuous glucose monitoring (CGM) improves glycemic awareness and self-management in non-insulin-treated (NIT) patients with type 2 diabetes (PwT2D). This study examined whether supplementing short-term CGM use of 9-14 days with access to a digital learning platform or a blended in-person course and webinar enhances self-reported […]
Read More1334-OR: Hepatocyte-Derived THBS2 Encodes Metabolic Stress to Orchestrate Immune-Stromal Remodeling
Introduction and Objective: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by chronic immune activation and stromal remodeling; however, the paracrine mechanisms linking parenchymal metabolic stress to immune-stromal responses remain poorly understood. This study aimed to identify key paracrine signals driving inflammatory and fibrogenic remodeling in MASH and to define their downstream mechanisms.Methods: Integrative transcriptomic and secretome […]
Read More1338-OR: Time and Educational Needs Required for Older Adults on Continuous Glucose Monitoring: A Mixed-Methods Study
Introduction and Objective: Older adults benefit from continuous glucose monitoring (CGM) use, but CGM initiation and sustained use often require intensive educator support, and time requirements are poorly characterized. We quantified educator time and support needs during the REST study.Methods: REST is a prospective 12-month study conducted in older adults (≥65 years) with insulin-treated diabetes, […]
Read MoreSuvorexant protects from ocular complications of diabetes in db/db mice
Introduction Orexins, hypothalamic neuropeptides, play a critical role in promoting wakefulness. Suvorexant, a dual orexin receptor antagonist, which is primarily indicated for the treatment of insomnia, also lowers blood glucose. Similarly, in rodent studies, suvorexant has shown beneficial effects on overall glucose homeostasis. Using an animal model of type 2 diabetes (T2D) db/db mice, we […]
Read More1300-OR: Performance of the iCan CGM System in a Pediatric Sample from a U.S. Multicenter Study
Introduction and Objective: The iCan CGM system is equipped with 3rd generation sensor technology and based on a different enzyme (GDH-FAD) than other FDA approved CGM systems in US. This 15d factory calibrated sensor is available in many regulated markets worldwide and was evaluated in a multi-center study for iCGM compliance in a pediatric sample […]
Read More1307-OR: Site-Specific Cancer Risk across Type 2 Diabetes Subtypes and Adults without Diabetes in a Real-World Cohort of 1.2 Million Adults
Introduction and Objective: Type 2 diabetes (T2D) is associated with elevated cancer risk, yet whether heterogeneity in T2D identifies individuals at particularly high or low risk relative to individuals without diabetes remains unclear. We evaluated site-specific cancer risk across T2D subtypes compared with adults without diabetes.Methods: We analyzed retrospective electronic health records from Epic Cosmos […]
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